DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
IRKTPKLT
Uniprot ID:
D6REC4
Source protein:
Cilia- and flagella-associated protein 99
Source gene:
CFAP99
Class:
DEG_SCF_FBW7_1
Location:
279:286
E3 ligase:
FBXW7
DEGRON score:
0.9925
ASA_SCORE:
111.0625
COIL:
0.9413
CONS_SCORE:
0.4537
DSS_SCORE:
0.3876
HELIX:
0.0235
FCONS_SCORE:
1.088
RIG_SCORE:
0.7838
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q274H
SIDM01608
Endometrial Carcinoma
GDSC
IRKTPKLT
DEG_SCF_FBW7_1
0.1944
Drug responses associated with CFAP99 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IRKTPKLT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
D6REC4
Cilia- and flagella-associated protein 99
DEG_SCF_FBW7_1
279:286
IRKTPKLT
FBXW7
0.9925
More...