DegronMD

Uniprot ID: Q9BZL6

Source protein: Serine/threonine-protein kinase D2

Source gene: PRKD2

Class: DEG_APCC_DBOX_1

Location: 504:512

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6824

ASA_SCORE: 70.9333

COIL: 0.5471

CONS_SCORE: 0.5738

DSS_SCORE: 0.4587

HELIX: 0.3631

FCONS_SCORE: 1.4768

RIG_SCORE: 0.8308

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R505C	TCGA-CM-4746	COAD	TCGA	IRQALMPVI	DEG_APCC_DBOX_1	0.8301
p.R505H	TCGA-FI-A2D5	UCEC	TCGA	IRQALMPVI	DEG_APCC_DBOX_1	0.8244
p.L508I	DO233903	GACA	ICGC	IRQALMPVI	DEG_APCC_DBOX_1	0.7174
p.K511N	DO2401	BRCA	ICGC	IRQALMPVI	DEG_APCC_DBOX_1	0.6918
p.P510H	ACH-001669	Leukemia	CCLE	IRQALMPVI	DEG_APCC_DBOX_1	0.6583
p.L518F	DO229240	THCA	ICGC	IRQALMPVI	DEG_APCC_DBOX_1	0.6111
p.A503T	TCGA-IB-7651	PAAD	TCGA	IRQALMPVI	DEG_APCC_DBOX_1	0.3056
p.T502I	TCGA-UY-A78O	BLCA	TCGA	IRQALMPVI	DEG_APCC_DBOX_1	0.2778
p.V514A	DO41331	UCEC	ICGC	IRQALMPVI	DEG_APCC_DBOX_1	0.2778
p.A516T	TCGA-CG-5726	STAD	TCGA	IRQALMPVI	DEG_APCC_DBOX_1	0.2222
p.A516T	TCGA-VQ-A8PB	STAD	TCGA	IRQALMPVI	DEG_APCC_DBOX_1	0.2222
p.A516T	SIDM01432	Kidney Carcinoma	GDSC	IRQALMPVI	DEG_APCC_DBOX_1	0.2222
p.A516T	ACH-000495	Kidney Cancer	CCLE	IRQALMPVI	DEG_APCC_DBOX_1	0.2222
p.W500S	ACH-001097	Lymphoma	CCLE	IRQALMPVI	DEG_APCC_DBOX_1	0.2222
p.I498V	DO38296	STAD	ICGC	IRQALMPVI	DEG_APCC_DBOX_1	0.1667
p.A497T	TCGA-A5-A0G2	UCEC	TCGA	IRQALMPVI	DEG_APCC_DBOX_1	0.1389
p.A519S	TCGA-QR-A70R	PCPG	TCGA	IRQALMPVI	DEG_APCC_DBOX_1	0.1389
p.A494D	TCGA-X6-A7WA	SARC	TCGA	IRQALMPVI	DEG_APCC_DBOX_1	0.0556
p.T494I	GEO	large_intestine	COSMIC	IRQALMPVI	DEG_APCC_DBOX_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZL6	Serine/threonine-protein kinase D2	DEG_APCC_DBOX_1	504:512	IRQALMPVI	APC,CDC20,FZR1	0.6824	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons