DegronMD

Uniprot ID: Q9NR09

Source protein: Baculoviral IAP repeat-containing protein 6

Source gene: BIRC6

Class: DEG_APCC_DBOX_1

Location: 2027:2035

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7687

ASA_SCORE: 21.1778

COIL: 0.0068

CONS_SCORE: 0.6369

DSS_SCORE: 0.0435

HELIX: 0.9922

FCONS_SCORE: 1.327

RIG_SCORE: 0.9395

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2024H	TCGA-2W-A8YY	CESC	TCGA	IRYLLDTLL	DEG_APCC_DBOX_1	0.25
p.R2024H	DO223732	CESC	ICGC	IRYLLDTLL	DEG_APCC_DBOX_1	0.25
p.T2025N	TCGA-AP-A059	UCEC	TCGA	IRYLLDTLL	DEG_APCC_DBOX_1	0.2778
p.T2025N	DO41361	UCEC	ICGC	IRYLLDTLL	DEG_APCC_DBOX_1	0.2778
p.S2045F	TCGA-AR-A2LE	BRCA	TCGA	IRYLLDTLL	DEG_APCC_DBOX_1	0.0556
p.S2045F	DO1932	BRCA	ICGC	IRYLLDTLL	DEG_APCC_DBOX_1	0.0556
p.R2024C	TCGA-AX-A2HC	UCEC	TCGA	IRYLLDTLL	DEG_APCC_DBOX_1	0.25
p.R2024C	DO233784	GACA	ICGC	IRYLLDTLL	DEG_APCC_DBOX_1	0.25
p.R2024C	DO41572	UCEC	ICGC	IRYLLDTLL	DEG_APCC_DBOX_1	0.25
p.I2026F	TCGA-D3-A8GL	SKCM	TCGA	IRYLLDTLL	DEG_APCC_DBOX_1	0.3056
p.I2026F	DO50287	SKCM	ICGC	IRYLLDTLL	DEG_APCC_DBOX_1	0.3056
p.E2021D	DO229019	LICA	ICGC	IRYLLDTLL	DEG_APCC_DBOX_1	0.1667
p.T2017A	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	IRYLLDTLL	DEG_APCC_DBOX_1	0.0556
p.T2017A	ACH-000769	Lung Cancer	CCLE	IRYLLDTLL	DEG_APCC_DBOX_1	0.0556
p.T2017A	LK-2	lung	COSMIC	IRYLLDTLL	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR09	Baculoviral IAP repeat-containing protein 6	DEG_APCC_DBOX_1	2027:2035	IRYLLDTLL	APC,CDC20,FZR1	0.7687	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons