DegronMD

Uniprot ID: Q08050

Source protein: Forkhead box protein M1

Source gene: FOXM1

Class: DEG_SCF_FBW7_1

Location: 608:615

E3 ligase: FBXW7

DEGRON score: 0.9964

ASA_SCORE: 86.2

COIL: 0.9366

CONS_SCORE: 0.5152

DSS_SCORE: 0.5595

HELIX: 0.0142

FCONS_SCORE: 1.1065

RIG_SCORE: 0.6699

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S620F	TCGA-73-4658	LUAD	TCGA	ISSTPSKS	DEG_SCF_FBW7_1	0.6389
p.S620F	DO23663	LUAD	ICGC	ISSTPSKS	DEG_SCF_FBW7_1	0.6389
p.A611T	TCGA-AA-3715	COAD	TCGA	ISSTPSKS	DEG_SCF_FBW7_1	0.7139
p.A611T	TCGA-AJ-A3BG	UCEC	TCGA	ISSTPSKS	DEG_SCF_FBW7_1	0.7139
p.A611T	DO8018	COAD	ICGC	ISSTPSKS	DEG_SCF_FBW7_1	0.7139
p.A611T	DO233652	GACA	ICGC	ISSTPSKS	DEG_SCF_FBW7_1	0.7139
p.A611T	DO42633	UCEC	ICGC	ISSTPSKS	DEG_SCF_FBW7_1	0.7139
p.A611T	SIDM00619	Thyroid Gland Carcinoma	GDSC	ISSTPSKS	DEG_SCF_FBW7_1	0.7139
p.A611T	KMH-2	thyroid	COSMIC	ISSTPSKS	DEG_SCF_FBW7_1	0.7139
p.S624T	TCGA-VQ-A8P2	STAD	TCGA	ISSTPSKS	DEG_SCF_FBW7_1	0.0833
p.S624T	DO51761	STAD	ICGC	ISSTPSKS	DEG_SCF_FBW7_1	0.0833
p.S619C	TCGA-XF-A9SI	BLCA	TCGA	ISSTPSKS	DEG_SCF_FBW7_1	0.2222
p.S619C	DO51914	BLCA	ICGC	ISSTPSKS	DEG_SCF_FBW7_1	0.2222
p.P622T	DO229006	LICA	ICGC	ISSTPSKS	DEG_SCF_FBW7_1	0.1389
p.F615I	DO45113	LIRI	ICGC	ISSTPSKS	DEG_SCF_FBW7_1	0.7415
p.P614L	SIDM00303	Ovarian Carcinoma	GDSC	ISSTPSKS	DEG_SCF_FBW7_1	0.7582
p.P614L	JHOS-4	ovary	COSMIC	ISSTPSKS	DEG_SCF_FBW7_1	0.7582
p.P606T	ACH-000967	Colon/Colorectal Cancer	CCLE	ISSTPSKS	DEG_SCF_FBW7_1	0.2778
p.W609C	ACH-001413	Bladder Cancer	CCLE	ISSTPSKS	DEG_SCF_FBW7_1	0.7
p.P618L	MCC13	skin	COSMIC	ISSTPSKS	DEG_SCF_FBW7_1	0.25
p.P618S	MCC13	skin	COSMIC	ISSTPSKS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08050	Forkhead box protein M1	DEG_SCF_FBW7_1	608:615	ISSTPSKS	FBXW7	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons