DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
ISTPEKE
Uniprot ID:
P28290
Source protein:
Protein ITPRID2
Source gene:
ITPRID2
Class:
DEG_SCF_FBW7_2
Location:
440:446
E3 ligase:
FBXW7
DEGRON score:
0.99
ASA_SCORE:
105.0429
COIL:
0.9359
CONS_SCORE:
0.5628
DSS_SCORE:
0.539
HELIX:
0.032
FCONS_SCORE:
0.9841
RIG_SCORE:
0.6697
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P450S
SIDM00330
Neuroblastoma
GDSC
ISTPEKE
DEG_SCF_FBW7_2
0.2222
p.P450S
LAN-6
autonomic_ganglia
COSMIC
ISTPEKE
DEG_SCF_FBW7_2
0.2222
Drug responses associated with ITPRID2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ISTPEKE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P28290
Protein ITPRID2
DEG_SCF_FBW7_2
440:446
ISTPEKE
FBXW7
0.99
More...