DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ISTPVQT
Uniprot ID:
Q2M2H8
Source protein:
Probable maltase-glucoamylase 2
Source gene:
MGAM2
Class:
DEG_SCF_FBW7_1
Location:
2141:2147
E3 ligase:
FBXW7
DEGRON score:
0.9704
ASA_SCORE:
85.8714
COIL:
0.8844
CONS_SCORE:
0
DSS_SCORE:
0.4707
HELIX:
0.0163
FCONS_SCORE:
0
RIG_SCORE:
0.764
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MGAM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ISTPVQT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SCF_FBW7_1
2141:2147
ISTPVQT
FBXW7
0.9704
More...