DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
ISVHPE
Uniprot ID:
Q5VYS8
Source protein:
Terminal uridylyltransferase 7
Source gene:
TUT7
Class:
LIG_APCC_ABBA_1
Location:
717:722
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9979
ASA_SCORE:
77.3
COIL:
0.7593
CONS_SCORE:
0.3774
DSS_SCORE:
0.6383
HELIX:
0.1577
FCONS_SCORE:
1.0655
RIG_SCORE:
0.6858
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TUT7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ISVHPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VYS8
Terminal uridylyltransferase 7
LIG_APCC_ABBA_1
717:722
ISVHPE
APC,CDC20,FZR1
0.9979
More...