DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ISVTPSLT
Uniprot ID:
Q2M2H8
Source protein:
Probable maltase-glucoamylase 2
Source gene:
MGAM2
Class:
DEG_SCF_FBW7_1
Location:
2100:2107
E3 ligase:
FBXW7
DEGRON score:
0.9446
ASA_SCORE:
75.6625
COIL:
0.708
CONS_SCORE:
0
DSS_SCORE:
0.3045
HELIX:
0.0171
FCONS_SCORE:
0
RIG_SCORE:
0.7848
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MGAM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ISVTPSLT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SCF_FBW7_1
2100:2107
ISVTPSLT
FBXW7
0.9446
More...