DegronMD

Uniprot ID: Q3B7T1

Source protein: Erythroid differentiation-related factor 1

Source gene: EDRF1

Class: LIG_APCC_ABBA_1

Location: 288:293

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8136

ASA_SCORE: 79.3

COIL: 0.6813

CONS_SCORE: 0.3087

DSS_SCORE: 0.4146

HELIX: 0.2158

FCONS_SCORE: 0.9044

RIG_SCORE: 0.8092

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D303Y	TCGA-19-5956	GBM	TCGA	ITLFND	LIG_APCC_ABBA_1	0.0556
p.N302H	TCGA-BS-A0UF	UCEC	TCGA	ITLFND	LIG_APCC_ABBA_1	0.0833
p.K301N	TCGA-D1-A17Q	UCEC	TCGA	ITLFND	LIG_APCC_ABBA_1	0.5556
p.G294R	TCGA-FI-A2D0	UCEC	TCGA	ITLFND	LIG_APCC_ABBA_1	0.3056
p.I288V	TCGA-VQ-A91X	STAD	TCGA	ITLFND	LIG_APCC_ABBA_1	0.5965
p.N292S	SIDM00267	Biliary Tract Carcinoma	GDSC	ITLFND	LIG_APCC_ABBA_1	0.5958
p.N292S	TGBC24TKB	biliary_tract	COSMIC	ITLFND	LIG_APCC_ABBA_1	0.5958
p.S297G	SIDM00210	Ovarian Carcinoma	GDSC	ITLFND	LIG_APCC_ABBA_1	0.2222
p.P290A	HCC1395	breast	COSMIC	ITLFND	LIG_APCC_ABBA_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3B7T1	Erythroid differentiation-related factor 1	LIG_APCC_ABBA_1	288:293	ITLFND	APC,CDC20,FZR1	0.8136	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons