DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ITLYLE
Uniprot ID:
Q58FF7
Source protein:
Putative heat shock protein HSP 90-beta-3
Source gene:
HSP90AB3P
Class:
LIG_APCC_ABBA_1
Location:
192:197
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6014
ASA_SCORE:
63.1
COIL:
0.3822
CONS_SCORE:
0.4341
DSS_SCORE:
0.3752
HELIX:
0.0738
FCONS_SCORE:
0.8732
RIG_SCORE:
0.8389
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with HSP90AB3P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ITLYLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q58FF7
Putative heat shock protein HSP 90-beta-3
LIG_APCC_ABBA_1
192:197
ITLYLE
APC,CDC20,FZR1
0.6014
More...