DegronMD

Uniprot ID: P42345

Source protein: Serine/threonine-protein kinase mTOR

Source gene: MTOR

Class: DEG_SCF_FBW7_1

Location: 313:318

E3 ligase: FBXW7

DEGRON score: 0.9722

ASA_SCORE: 49.8833

COIL: 0.6238

CONS_SCORE: 0.0936

DSS_SCORE: 0.4245

HELIX: 0.2332

FCONS_SCORE: 0.8773

RIG_SCORE: 0.8074

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M304I	TCGA-44-6145	LUAD	TCGA	ITPFTS	DEG_SCF_FBW7_1	0.0833
p.M304I	DO25123	LUAD	ICGC	ITPFTS	DEG_SCF_FBW7_1	0.0833
p.R311C	TCGA-BR-8382	STAD	TCGA	ITPFTS	DEG_SCF_FBW7_1	0.2778
p.R311C	DO47925	STAD	ICGC	ITPFTS	DEG_SCF_FBW7_1	0.2778
p.R311H	TCGA-WS-AB45	COAD	TCGA	ITPFTS	DEG_SCF_FBW7_1	0.2778
p.R311H	DO51734	COAD	ICGC	ITPFTS	DEG_SCF_FBW7_1	0.2778
p.A321V	DO228138	PBCA	ICGC	ITPFTS	DEG_SCF_FBW7_1	0.25

Drug responses associated with MTOR mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00901	UCEC\|endometrium	p.G803* (No)	GDSC	Voxtalisib	21.5643
SIDM00901	UCEC\|endometrium	p.G803* (No)	GDSC	Temsirolimus	0.0311
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.Q188* (No)	GDSC	Temsirolimus	0.0888
SIDM00498	COREAD\|large_intestine	p.R1896* (No)	GDSC	Voxtalisib	219.2764
SIDM00498	COREAD\|large_intestine	p.R1896* (No)	GDSC	Temsirolimus	0.2884
SIDM00498	COREAD\|large_intestine	p.R1896* (No)	GDSC	QL-VIII-58	0.3386
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.C1483Y (No)	GDSC	Temsirolimus	0.0031
SIDM00771	LUAD\|lung_NSCLC_adenocarcinoma	p.Q2072* (No)	GDSC	Voxtalisib	56.7962
SIDM00771	LUAD\|lung_NSCLC_adenocarcinoma	p.Q2072* (No)	GDSC	Temsirolimus	0.1721
SIDM00771	LUAD\|lung_NSCLC_adenocarcinoma	p.Q2072* (No)	GDSC	QL-VIII-58	0.1561
SIDM01206	NB\|neuroblastoma	p.F1888V (No)	GDSC	JW-7-52-1	0.107
SIDM01206	NB\|neuroblastoma	p.F1888V (No)	GDSC	Voxtalisib	18.5347
SIDM01206	NB\|neuroblastoma	p.F1888V (No)	GDSC	Temsirolimus	1.7238
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.S2215F (No)	GDSC	JW-7-52-1	0.3796
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.S2215F (No)	GDSC	Voxtalisib	72.4925
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.S2215F (No)	GDSC	Temsirolimus	0.0633
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.S2215F (No)	GDSC	QL-VIII-58	0.1831
SIDM00333	UCEC\|endometrium	p.R766fs*24 (No)	GDSC	Voxtalisib	51.8381
SIDM00333	UCEC\|endometrium	p.R766fs*24 (No)	GDSC	Temsirolimus	0.003
SIDM00333	UCEC\|endometrium	p.R766fs*24 (No)	GDSC	QL-VIII-58	0.0589
SIDM00118	COREAD\|large_intestine	p.I2500M (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.I2500M (No)	GDSC	Temsirolimus	1.1908
SIDM00118	COREAD\|large_intestine	p.I2500M (No)	GDSC	QL-VIII-58	0.0483
SIDM00118	COREAD\|large_intestine	p.R1161* (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.R1161* (No)	GDSC	Temsirolimus	1.1908
SIDM00118	COREAD\|large_intestine	p.R1161* (No)	GDSC	QL-VIII-58	0.0483
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.V1591L (No)	GDSC	JW-7-52-1	0.0131
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.V1591L (No)	GDSC	Voxtalisib	387.875
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.V1591L (No)	GDSC	Temsirolimus	0.1309
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.V1591L (No)	GDSC	QL-VIII-58	0.2248
SIDM00795	SKCM\|melanoma	p.R2152C (No)	GDSC	Voxtalisib	10.1818
SIDM00795	SKCM\|melanoma	p.R2152C (No)	GDSC	Temsirolimus	0.0209
SIDM00795	SKCM\|melanoma	p.R2152C (No)	GDSC	QL-VIII-58	0.2372
SIDM00190	SKCM\|melanoma	p.M135T (No)	GDSC	JW-7-52-1	0.2109
SIDM00190	SKCM\|melanoma	p.M135T (No)	GDSC	Voxtalisib	84.7699
SIDM00190	SKCM\|melanoma	p.M135T (No)	GDSC	Temsirolimus	0.4286
SIDM00572	STAD\|stomach	p.P1951S (No)	GDSC	Voxtalisib	212.5036
SIDM00572	STAD\|stomach	p.P1951S (No)	GDSC	Temsirolimus	0.0156
SIDM00826	COREAD\|large_intestine	p.P1193L (No)	GDSC	Voxtalisib	137.4487
SIDM00826	COREAD\|large_intestine	p.P1193L (No)	GDSC	Temsirolimus	0.398
SIDM00499	PRAD\|prostate	p.R1749Q (No)	GDSC	Voxtalisib	137.4821
SIDM00499	PRAD\|prostate	p.R1749Q (No)	GDSC	Temsirolimus	0.0788
SIDM00499	PRAD\|prostate	p.R1749Q (No)	GDSC	QL-VIII-58	0.0969
SIDM00499	PRAD\|prostate	p.V420I (No)	GDSC	Voxtalisib	137.4821
SIDM00499	PRAD\|prostate	p.V420I (No)	GDSC	Temsirolimus	0.0788
SIDM00499	PRAD\|prostate	p.V420I (No)	GDSC	QL-VIII-58	0.0969
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P1254T (No)	GDSC	JW-7-52-1	0.0436
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P1254T (No)	GDSC	Voxtalisib	20.4243
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P1254T (No)	GDSC	Temsirolimus	0.224
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P1254T (No)	GDSC	QL-VIII-58	0.2462
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.M825I (No)	GDSC	JW-7-52-1	0.0436
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.M825I (No)	GDSC	Voxtalisib	20.4243
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.M825I (No)	GDSC	Temsirolimus	0.224
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.M825I (No)	GDSC	QL-VIII-58	0.2462
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.S275T (No)	GDSC	JW-7-52-1	0.0436
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.S275T (No)	GDSC	Voxtalisib	20.4243
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.S275T (No)	GDSC	Temsirolimus	0.224
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.S275T (No)	GDSC	QL-VIII-58	0.2462
SIDM00145	ALL\|lymphoblastic_leukemia	p.A1134T (No)	GDSC	JW-7-52-1	0.0731
SIDM00145	ALL\|lymphoblastic_leukemia	p.A1134T (No)	GDSC	Voxtalisib	29.7542
SIDM00145	ALL\|lymphoblastic_leukemia	p.A1134T (No)	GDSC	Temsirolimus	0.0128
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.A1134V (No)	GDSC	Voxtalisib	68.7291
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.A1134V (No)	GDSC	Temsirolimus	0.1081
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.A1134V (No)	GDSC	QL-VIII-58	0.2338
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.W1456R (No)	GDSC	JW-7-52-1	0.0157
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.W1456R (No)	GDSC	Voxtalisib	10.9668
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.W1456R (No)	GDSC	Temsirolimus	0.2517
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.W1456R (No)	GDSC	QL-VIII-58	0.5448
SIDM00661	DLBC\|B_cell_lymphoma	p.N1765D (No)	GDSC	JW-7-52-1	0.0827
SIDM00661	DLBC\|B_cell_lymphoma	p.N1765D (No)	GDSC	Voxtalisib	58.3139
SIDM00661	DLBC\|B_cell_lymphoma	p.N1765D (No)	GDSC	Temsirolimus	0.0506
SIDM00901	UCEC\|endometrium	p.R1201Q (No)	GDSC	Voxtalisib	21.5643
SIDM00901	UCEC\|endometrium	p.R1201Q (No)	GDSC	Temsirolimus	0.0311
SIDM00334	UCEC\|endometrium	p.R1482C (No)	GDSC	Voxtalisib	42.2335
SIDM00334	UCEC\|endometrium	p.R1482C (No)	GDSC	Temsirolimus	0.0096
SIDM00334	UCEC\|endometrium	p.R1482C (No)	GDSC	QL-VIII-58	0.0735
SIDM00603	HNSC\|head_and_neck	p.A1134V (No)	GDSC	Voxtalisib	125.4869
SIDM00603	HNSC\|head_and_neck	p.A1134V (No)	GDSC	Temsirolimus	0.0807
SIDM00781	COREAD\|large_intestine	p.F316fs*50 (Yes)	GDSC	JW-7-52-1	0.2173
SIDM00781	COREAD\|large_intestine	p.F316fs*50 (Yes)	GDSC	Voxtalisib	169.812
SIDM00781	COREAD\|large_intestine	p.F316fs*50 (Yes)	GDSC	Temsirolimus	0.285
SIDM00781	COREAD\|large_intestine	p.F316fs*50 (Yes)	GDSC	QL-VIII-58	0.97
SIDM00266	UNCLASSIFIED\|ewings_sarcoma	p.Q1207P (No)	GDSC	JW-7-52-1	0.039
SIDM00266	UNCLASSIFIED\|ewings_sarcoma	p.Q1207P (No)	GDSC	Voxtalisib	263.7211
SIDM00266	UNCLASSIFIED\|ewings_sarcoma	p.Q1207P (No)	GDSC	Temsirolimus	0.0253
SIDM00266	UNCLASSIFIED\|ewings_sarcoma	p.Q1207P (No)	GDSC	QL-VIII-58	0.0342
SIDM00098	MESO\|mesothelioma	p.L1037V (No)	GDSC	Voxtalisib	179.0272
SIDM00098	MESO\|mesothelioma	p.L1037V (No)	GDSC	Temsirolimus	0.1777
SIDM00098	MESO\|mesothelioma	p.L1037V (No)	GDSC	QL-VIII-58	0.409
SIDM00098	MESO\|mesothelioma	p.R260Q (No)	GDSC	Voxtalisib	179.0272
SIDM00098	MESO\|mesothelioma	p.R260Q (No)	GDSC	Temsirolimus	0.1777
SIDM00098	MESO\|mesothelioma	p.R260Q (No)	GDSC	QL-VIII-58	0.409
SIDM00781	COREAD\|large_intestine	p.E2491D (No)	GDSC	JW-7-52-1	0.2173
SIDM00781	COREAD\|large_intestine	p.E2491D (No)	GDSC	Voxtalisib	169.812
SIDM00781	COREAD\|large_intestine	p.E2491D (No)	GDSC	Temsirolimus	0.285
SIDM00781	COREAD\|large_intestine	p.E2491D (No)	GDSC	QL-VIII-58	0.97
SIDM00781	COREAD\|large_intestine	p.R398C (No)	GDSC	JW-7-52-1	0.2173
SIDM00781	COREAD\|large_intestine	p.R398C (No)	GDSC	Voxtalisib	169.812
SIDM00781	COREAD\|large_intestine	p.R398C (No)	GDSC	Temsirolimus	0.285
SIDM00781	COREAD\|large_intestine	p.R398C (No)	GDSC	QL-VIII-58	0.97
SIDM00142	UCEC\|endometrium	p.T2509A (No)	GDSC	JW-7-52-1	0.0585
SIDM00142	UCEC\|endometrium	p.T2509A (No)	GDSC	Voxtalisib	43.6877
SIDM00142	UCEC\|endometrium	p.T2509A (No)	GDSC	Temsirolimus	0.0278
SIDM00142	UCEC\|endometrium	p.T2509A (No)	GDSC	QL-VIII-58	0.0638
SIDM00980	STAD\|stomach	p.H262R (No)	GDSC	Voxtalisib	30.6098
SIDM00980	STAD\|stomach	p.H262R (No)	GDSC	Temsirolimus	0.0565
SIDM00980	STAD\|stomach	p.I261V (No)	GDSC	Voxtalisib	30.6098
SIDM00980	STAD\|stomach	p.I261V (No)	GDSC	Temsirolimus	0.0565
SIDM00666	LGG\|glioma	p.E1799K (No)	GDSC	Voxtalisib	86.1679
SIDM00666	LGG\|glioma	p.E1799K (No)	GDSC	Temsirolimus	0.0773
SIDM00666	LGG\|glioma	p.E1799K (No)	GDSC	QL-VIII-58	0.5659
SIDM00551	ESCA\|oesophagus	p.E2000Q (No)	GDSC	Voxtalisib	98.9769
SIDM00551	ESCA\|oesophagus	p.E2000Q (No)	GDSC	Temsirolimus	0.5448
SIDM00551	ESCA\|oesophagus	p.E2000Q (No)	GDSC	QL-VIII-58	1.4191
SIDM00437	LAML\|acute_myeloid_leukaemia	p.T571K (No)	GDSC	JW-7-52-1	0.0348
SIDM00437	LAML\|acute_myeloid_leukaemia	p.T571K (No)	GDSC	Voxtalisib	59.1462
SIDM00437	LAML\|acute_myeloid_leukaemia	p.T571K (No)	GDSC	Temsirolimus	0.0878
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.F140L (No)	GDSC	Voxtalisib	187.5287
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.F140L (No)	GDSC	Temsirolimus	0.3795
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.F140L (No)	GDSC	QL-VIII-58	2.7109
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.R2430M (No)	GDSC	Temsirolimus	0.0031
SIDM00488	COREAD\|large_intestine	p.P1537S (No)	GDSC	Voxtalisib	245.3216
SIDM00488	COREAD\|large_intestine	p.P1537S (No)	GDSC	Temsirolimus	1.11
SIDM00488	COREAD\|large_intestine	p.P1537S (No)	GDSC	QL-VIII-58	0.1352
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P2466S (No)	GDSC	JW-7-52-1	0.0217
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P2466S (No)	GDSC	Voxtalisib	31.6448
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P2466S (No)	GDSC	Temsirolimus	0.0039
SIDM00619	THCA\|thyroid	p.P1128L (No)	GDSC	Voxtalisib	21.6308
SIDM00619	THCA\|thyroid	p.P1128L (No)	GDSC	Temsirolimus	0.0735
SIDM00619	THCA\|thyroid	p.P1128L (No)	GDSC	QL-VIII-58	0.2299
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.M1V (No)	GDSC	JW-7-52-1	0.16
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.M1V (No)	GDSC	Voxtalisib	21.9483
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.M1V (No)	GDSC	Temsirolimus	0.2066
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.M1V (No)	GDSC	QL-VIII-58	0.0652
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.F1545L (No)	GDSC	JW-7-52-1	0.16
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.F1545L (No)	GDSC	Voxtalisib	21.9483
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.F1545L (No)	GDSC	Temsirolimus	0.2066
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.F1545L (No)	GDSC	QL-VIII-58	0.0652
SIDM01045	UCEC\|endometrium	p.Y861H (No)	GDSC	Voxtalisib	85.432
SIDM01045	UCEC\|endometrium	p.Y861H (No)	GDSC	Temsirolimus	0.1675
SIDM01045	UCEC\|endometrium	p.Y861H (No)	GDSC	QL-VIII-58	1.2478
SIDM01028	ESCA\|oesophagus	p.R1709H (No)	GDSC	Voxtalisib	281.1758
SIDM01028	ESCA\|oesophagus	p.R1709H (No)	GDSC	Temsirolimus	0.0206
SIDM01028	ESCA\|oesophagus	p.R1709H (No)	GDSC	QL-VIII-58	0.1261
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	JW-7-52-1	0.1344
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	Voxtalisib	122.0187
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	Temsirolimus	0.211
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	QL-VIII-58	0.1306
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.P2490A (No)	GDSC	JW-7-52-1	0.1165
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.P2490A (No)	GDSC	Voxtalisib	58.2367
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.P2490A (No)	GDSC	Temsirolimus	0.0776
SIDM00333	UCEC\|endometrium	p.K1981E (No)	GDSC	Voxtalisib	51.8381
SIDM00333	UCEC\|endometrium	p.K1981E (No)	GDSC	Temsirolimus	0.003
SIDM00333	UCEC\|endometrium	p.K1981E (No)	GDSC	QL-VIII-58	0.0589
SIDM01193	GBM\|glioma	p.L1129P (No)	GDSC	Voxtalisib	134.8685
SIDM01217	ALL\|leukemia	p.W1449_H1454delinsAL (No)	GDSC	JW-7-52-1	0.0068
SIDM01217	ALL\|leukemia	p.W1449_H1454delinsAL (No)	GDSC	Voxtalisib	46.3581
SIDM01217	ALL\|leukemia	p.W1449_H1454delinsAL (No)	GDSC	Temsirolimus	0.0112
SIDM00217	COREAD\|large_intestine	p.R1208C (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.T1143M (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.S1087N (No)	GDSC	Voxtalisib	169.1451
SIDM00140	SKCM\|melanoma	p.P453L (No)	GDSC	Voxtalisib	130.0637
SIDM00140	SKCM\|melanoma	p.P453L (No)	GDSC	Temsirolimus	0.1542
SIDM00466	OV\|ovary	p.T1834_T1837delTAAT (No)	GDSC	Voxtalisib	1260.2281
SIDM00466	OV\|ovary	p.T1834_T1837delTAAT (No)	GDSC	Temsirolimus	0.5714
SIDM00466	OV\|ovary	p.T1834_T1837delTAAT (No)	GDSC	QL-VIII-58	2.2905
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.G1491S (No)	GDSC	JW-7-52-1	0.1008
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.G1491S (No)	GDSC	Voxtalisib	38.3355
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.G1491S (No)	GDSC	Temsirolimus	0.0541
SIDM00216	COREAD\|large_intestine	p.T588M (No)	GDSC	Voxtalisib	21.2501
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.L573F (No)	GDSC	Voxtalisib	43.6878
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.L573F (No)	GDSC	Temsirolimus	0.0278
SIDM00231	KIRC\|kidney	p.L2209V (No)	GDSC	Temsirolimus	0.1737
SIDM00231	KIRC\|kidney	p.L2209V (No)	GDSC	QL-VIII-58	2.0362
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.L2427R (No)	GDSC	JW-7-52-1	0.7719
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.L2427R (No)	GDSC	Voxtalisib	14.8856
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.L2427R (No)	GDSC	Temsirolimus	0.083
SIDM00282	COREAD\|large_intestine	p.G2238D (No)	GDSC	JW-7-52-1	12.9145
SIDM00282	COREAD\|large_intestine	p.G2238D (No)	GDSC	Voxtalisib	116.8252
SIDM00282	COREAD\|large_intestine	p.G2238D (No)	GDSC	Temsirolimus	4.6851
SIDM00282	COREAD\|large_intestine	p.G2238D (No)	GDSC	QL-VIII-58	22.133
SIDM00282	COREAD\|large_intestine	p.P1408S (No)	GDSC	JW-7-52-1	12.9145
SIDM00282	COREAD\|large_intestine	p.P1408S (No)	GDSC	Voxtalisib	116.8252
SIDM00282	COREAD\|large_intestine	p.P1408S (No)	GDSC	Temsirolimus	4.6851
SIDM00282	COREAD\|large_intestine	p.P1408S (No)	GDSC	QL-VIII-58	22.133
SIDM00282	COREAD\|large_intestine	p.M488I (No)	GDSC	JW-7-52-1	12.9145
SIDM00282	COREAD\|large_intestine	p.M488I (No)	GDSC	Voxtalisib	116.8252
SIDM00282	COREAD\|large_intestine	p.M488I (No)	GDSC	Temsirolimus	4.6851
SIDM00282	COREAD\|large_intestine	p.M488I (No)	GDSC	QL-VIII-58	22.133
SIDM00613	LGG\|glioma	p.R1208C (No)	GDSC	JW-7-52-1	0.0283
SIDM00613	LGG\|glioma	p.R1208C (No)	GDSC	Voxtalisib	397.1146
SIDM00613	LGG\|glioma	p.R1208C (No)	GDSC	Temsirolimus	0.0667
SIDM00150	COREAD\|large_intestine	p.P1254L (No)	GDSC	JW-7-52-1	0.0843
SIDM00150	COREAD\|large_intestine	p.P1254L (No)	GDSC	Voxtalisib	131.4537
SIDM00150	COREAD\|large_intestine	p.P1254L (No)	GDSC	Temsirolimus	0.2944
SIDM00150	COREAD\|large_intestine	p.P1254L (No)	GDSC	QL-VIII-58	3.8198
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.V1801G (No)	GDSC	Voxtalisib	171.7416
SIDM00609	KIRC\|kidney	p.W1304R (No)	GDSC	Voxtalisib	149.8482
SIDM00609	KIRC\|kidney	p.W1304R (No)	GDSC	Temsirolimus	0.0656
SIDM00609	KIRC\|kidney	p.W1304R (No)	GDSC	QL-VIII-58	0.9736
SIDM01026	ESCA\|oesophagus	p.R1208C (No)	GDSC	Voxtalisib	93.4419
SIDM00534	COREAD\|large_intestine	p.A695V (No)	GDSC	Voxtalisib	109.0545
SIDM00534	COREAD\|large_intestine	p.A695V (No)	GDSC	Temsirolimus	1.5935
SIDM00534	COREAD\|large_intestine	p.A695V (No)	GDSC	QL-VIII-58	1.7963
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1609L (No)	GDSC	JW-7-52-1	5.6514
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1609L (No)	GDSC	Voxtalisib	64.7542
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1609L (No)	GDSC	Temsirolimus	1.22
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1609L (No)	GDSC	QL-VIII-58	0.885
SIDM00487	COREAD\|large_intestine	p.L342P (No)	GDSC	Voxtalisib	34.8403
SIDM00487	COREAD\|large_intestine	p.L342P (No)	GDSC	Temsirolimus	2.8221
SIDM00487	COREAD\|large_intestine	p.L342P (No)	GDSC	QL-VIII-58	1.7019
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312L (No)	GDSC	JW-7-52-1	0.0205
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312L (No)	GDSC	Voxtalisib	35.8859
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312L (No)	GDSC	Temsirolimus	0.0236
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312L (No)	GDSC	QL-VIII-58	0.1273
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312S (No)	GDSC	JW-7-52-1	0.0205
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312S (No)	GDSC	Voxtalisib	35.8859
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312S (No)	GDSC	Temsirolimus	0.0236
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312S (No)	GDSC	QL-VIII-58	0.1273
SIDM00414	BLCA\|bladder	p.E1033K (No)	GDSC	Voxtalisib	134.1279
SIDM00414	BLCA\|bladder	p.E1033K (No)	GDSC	Temsirolimus	0.0211
SIDM00820	KIRC\|kidney	p.P770A (No)	GDSC	Voxtalisib	45.5299
SIDM00820	KIRC\|kidney	p.P770A (No)	GDSC	Temsirolimus	0.058
SIDM00820	KIRC\|kidney	p.P770A (No)	GDSC	QL-VIII-58	1.4707
SIDM00083	LGG\|glioma	p.M476V (No)	GDSC	JW-7-52-1	0.7926
SIDM00083	LGG\|glioma	p.M476V (No)	GDSC	Voxtalisib	42.3339
SIDM00083	LGG\|glioma	p.M476V (No)	GDSC	Temsirolimus	0.0673
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.H1647Q (No)	GDSC	Voxtalisib	122.2226
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.H1647Q (No)	GDSC	Temsirolimus	0.2295
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.K1197N (No)	GDSC	Voxtalisib	72.3957
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.K1197N (No)	GDSC	Temsirolimus	0.2383
SIDM01233	COREAD\|large_intestine	p.Y1151C (No)	GDSC	JW-7-52-1	0.7438
SIDM01233	COREAD\|large_intestine	p.Y1151C (No)	GDSC	Voxtalisib	139.1593
SIDM01233	COREAD\|large_intestine	p.Y1151C (No)	GDSC	Temsirolimus	0.1617
SIDM01233	COREAD\|large_intestine	p.Y1151C (No)	GDSC	QL-VIII-58	3.9052
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.I2017T (No)	GDSC	JW-7-52-1	0.0097
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.I2017T (No)	GDSC	Voxtalisib	75.1955
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.I2017T (No)	GDSC	Temsirolimus	0.011
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.I2017T (No)	GDSC	QL-VIII-58	0.0686
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.S645C (No)	GDSC	Voxtalisib	192.582
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.S645C (No)	GDSC	Temsirolimus	0.2147
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.S645C (No)	GDSC	QL-VIII-58	0.1935
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S383G (No)	GDSC	JW-7-52-1	0.084
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S383G (No)	GDSC	Voxtalisib	35.8215
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S383G (No)	GDSC	Temsirolimus	0.1032
SIDM00779	COREAD\|large_intestine	p.L1666R (No)	GDSC	JW-7-52-1	12.0633
SIDM00779	COREAD\|large_intestine	p.L1666R (No)	GDSC	Voxtalisib	238.6089
SIDM00779	COREAD\|large_intestine	p.L1666R (No)	GDSC	Temsirolimus	0.2747
SIDM00779	COREAD\|large_intestine	p.L1666R (No)	GDSC	QL-VIII-58	2.1347
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.T2471M (No)	GDSC	JW-7-52-1	1.8322
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.T2471M (No)	GDSC	Voxtalisib	368.4887
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.T2471M (No)	GDSC	Temsirolimus	0.1728
SIDM00360	UNCLASSIFIED\|pancreas	p.R1811H (No)	GDSC	Voxtalisib	852.3455
SIDM00360	UNCLASSIFIED\|pancreas	p.R1811H (No)	GDSC	Temsirolimus	0.4247
SIDM00360	UNCLASSIFIED\|pancreas	p.R1811H (No)	GDSC	QL-VIII-58	0.8073
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.A41T (No)	GDSC	JW-7-52-1	0.0254
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.A41T (No)	GDSC	Voxtalisib	12.5998
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.A41T (No)	GDSC	Temsirolimus	0.0368
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.D259Y (No)	GDSC	Voxtalisib	168.3281
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.D259Y (No)	GDSC	Temsirolimus	0.0814
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.D259Y (No)	GDSC	QL-VIII-58	0.2089
SIDM00890	SKCM\|melanoma	p.R1612Q (No)	GDSC	Voxtalisib	199.5219
SIDM00890	SKCM\|melanoma	p.R1612Q (No)	GDSC	Temsirolimus	0.0669
SIDM00890	SKCM\|melanoma	p.R1612Q (No)	GDSC	QL-VIII-58	0.7659
SIDM00444	ESCA\|oesophagus	p.D1332E (No)	GDSC	Voxtalisib	80.6232
SIDM00444	ESCA\|oesophagus	p.D1332E (No)	GDSC	Temsirolimus	1.0691
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.T2232I (No)	GDSC	JW-7-52-1	0.7498
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.T2232I (No)	GDSC	Voxtalisib	59.2226
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.T2232I (No)	GDSC	Temsirolimus	0.4096
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A1728S (No)	GDSC	Voxtalisib	44.3158
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A1728S (No)	GDSC	Temsirolimus	1.2607
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A1728S (No)	GDSC	QL-VIII-58	0.7118
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A41P (No)	GDSC	Voxtalisib	44.3158
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A41P (No)	GDSC	Temsirolimus	1.2607
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A41P (No)	GDSC	QL-VIII-58	0.7118
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	JW-7-52-1	0.0372
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	Voxtalisib	42.8346
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	Temsirolimus	0.0089
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	QL-VIII-58	0.05
SIDM00537	COREAD\|large_intestine	p.T1948M (No)	GDSC	Voxtalisib	46.0663
SIDM00537	COREAD\|large_intestine	p.T1948M (No)	GDSC	Temsirolimus	0.7728
SIDM00537	COREAD\|large_intestine	p.T1948M (No)	GDSC	QL-VIII-58	0.4692
SIDM01146	STAD\|stomach	p.T431A (No)	GDSC	JW-7-52-1	0.3203
SIDM01146	STAD\|stomach	p.T431A (No)	GDSC	Voxtalisib	19.3856
SIDM00562	BRCA\|breast	p.E427D (No)	GDSC	Voxtalisib	21.4042
SIDM00562	BRCA\|breast	p.E427D (No)	GDSC	Temsirolimus	0.1894
SIDM00238	OV\|ovary	p.T647I (No)	GDSC	Voxtalisib	273.5461
SIDM00238	OV\|ovary	p.T647I (No)	GDSC	Temsirolimus	0.0026
SIDM00238	OV\|ovary	p.T647I (No)	GDSC	QL-VIII-58	0.1126
SIDM00878	BRCA\|breast	p.Q2072R (No)	GDSC	Voxtalisib	105.6871
SIDM00878	BRCA\|breast	p.Q2072R (No)	GDSC	Temsirolimus	1.0967
SIDM00878	BRCA\|breast	p.Q2072R (No)	GDSC	QL-VIII-58	0.1555
SIDM00878	BRCA\|breast	p.H642R (No)	GDSC	Voxtalisib	105.6871
SIDM00878	BRCA\|breast	p.H642R (No)	GDSC	Temsirolimus	1.0967
SIDM00878	BRCA\|breast	p.H642R (No)	GDSC	QL-VIII-58	0.1555
SIDM00410	ALL\|lymphoid_neoplasm_other	p.P1408S (No)	GDSC	JW-7-52-1	10.6824
SIDM00410	ALL\|lymphoid_neoplasm_other	p.P1408S (No)	GDSC	Voxtalisib	22.3813
SIDM00410	ALL\|lymphoid_neoplasm_other	p.P1408S (No)	GDSC	Temsirolimus	0.0055
SIDM00817	KIRC\|kidney	p.L2138F (No)	GDSC	Voxtalisib	69.0575
SIDM00817	KIRC\|kidney	p.L2138F (No)	GDSC	Temsirolimus	0.0023
SIDM00817	KIRC\|kidney	p.L2138F (No)	GDSC	QL-VIII-58	0.0586
SIDM00193	COREAD\|large_intestine	p.L1894V (No)	GDSC	Voxtalisib	56.6765
SIDM00193	COREAD\|large_intestine	p.L1894V (No)	GDSC	Temsirolimus	0.0143
SIDM00193	COREAD\|large_intestine	p.L1894V (No)	GDSC	QL-VIII-58	0.3664
SIDM00118	COREAD\|large_intestine	p.C1497F (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.C1497F (No)	GDSC	Temsirolimus	1.1908
SIDM00118	COREAD\|large_intestine	p.C1497F (No)	GDSC	QL-VIII-58	0.0483
SIDM00118	COREAD\|large_intestine	p.R281C (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.R281C (No)	GDSC	Temsirolimus	1.1908
SIDM00118	COREAD\|large_intestine	p.R281C (No)	GDSC	QL-VIII-58	0.0483

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPFTS

Degron related mutations and impact score

Drug responses associated with MTOR mutations

All proteins holding degron of ITPFTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42345	Serine/threonine-protein kinase mTOR	DEG_SCF_FBW7_1	313:318	ITPFTS	FBXW7	0.9722	More...