DegronMD

Uniprot ID: O15232

Source protein: Matrilin-3

Source gene: MATN3

Class: DEG_SCF_FBW7_1

Location: 153:158

E3 ligase: FBXW7

DEGRON score: 0.6768

ASA_SCORE: 45.2333

COIL: 0.875

CONS_SCORE: 0.5643

DSS_SCORE: 0.3071

HELIX: 0.0528

FCONS_SCORE: 0.9005

RIG_SCORE: 0.7634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R152Q	TCGA-17-Z026	LUAD	TCGA	ITPLST	DEG_SCF_FBW7_1	0.3056
p.V150M	TCGA-A5-A1OF	UCEC	TCGA	ITPLST	DEG_SCF_FBW7_1	0.25
p.V150M	DO42568	UCEC	ICGC	ITPLST	DEG_SCF_FBW7_1	0.25
p.Q167K	TCGA-CN-6010	HNSC	TCGA	ITPLST	DEG_SCF_FBW7_1	0.0833
p.Q167K	DO14766	HNSC	ICGC	ITPLST	DEG_SCF_FBW7_1	0.0833
p.Q167H	TCGA-DK-A3X1	BLCA	TCGA	ITPLST	DEG_SCF_FBW7_1	0.0833
p.Q167H	DO447	BLCA	ICGC	ITPLST	DEG_SCF_FBW7_1	0.0833
p.T168I	DO222519	COCA	ICGC	ITPLST	DEG_SCF_FBW7_1	0.0556
p.S162A	DO233686	GACA	ICGC	ITPLST	DEG_SCF_FBW7_1	0.2222
p.A165D	DO229018	LICA	ICGC	ITPLST	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15232	Matrilin-3	DEG_SCF_FBW7_1	153:158	ITPLST	FBXW7	0.6768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons