DegronMD

Uniprot ID: Q86T13

Source protein: C-type lectin domain family 14 member A

Source gene: CLEC14A

Class: DEG_SCF_FBW7_1

Location: 370:375

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 77.9

COIL: 0.9292

CONS_SCORE: 0.7414

DSS_SCORE: 0.3693

HELIX: 0.0272

FCONS_SCORE: 1.2139

RIG_SCORE: 0.6821

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S375R	TCGA-A5-A0G2	UCEC	TCGA	ITPSGS	DEG_SCF_FBW7_1	0.7427
p.S375R	DO41235	UCEC	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.7427
p.E365K	TCGA-AP-A056	UCEC	TCGA	ITPSGS	DEG_SCF_FBW7_1	0.1944
p.E365K	TCGA-E7-A4IJ	BLCA	TCGA	ITPSGS	DEG_SCF_FBW7_1	0.1944
p.E365K	DO453	BLCA	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.1944
p.E365K	DO43971	UCEC	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.1944
p.L362I	TCGA-AP-A1DK	UCEC	TCGA	ITPSGS	DEG_SCF_FBW7_1	0.1111
p.L362I	DO42033	UCEC	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.1111
p.T383M	TCGA-CG-4460	STAD	TCGA	ITPSGS	DEG_SCF_FBW7_1	0.1111
p.T383M	DO38427	STAD	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.1111
p.P372T	TCGA-D3-A2J6	SKCM	TCGA	ITPSGS	DEG_SCF_FBW7_1	0.7031
p.P372T	DO37901	SKCM	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.7031
p.N381K	TCGA-VQ-A91K	STAD	TCGA	ITPSGS	DEG_SCF_FBW7_1	0.1667
p.N381K	DO51785	STAD	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.1667
p.V376M	DO228460	BRCA	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.3056
p.T369N	DO229018	LICA	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.3056
p.G374E	DO220879	MELA	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.6087
p.S385F	DO222644	MELA	ICGC	ITPSGS	DEG_SCF_FBW7_1	0.0556
p.S378Y	ACH-001719	Ovarian Cancer	CCLE	ITPSGS	DEG_SCF_FBW7_1	0.25
p.S382F	ACH-002396	Bone Cancer	CCLE	ITPSGS	DEG_SCF_FBW7_1	0.1389
p.S382F	Sarc9371	bone	COSMIC	ITPSGS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86T13	C-type lectin domain family 14 member A	DEG_SCF_FBW7_1	370:375	ITPSGS	FBXW7	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons