DegronMD

Uniprot ID: Q6PJG2

Source protein: Mitotic deacetylase-associated SANT domain protein

Source gene: MIDEAS

Class: DEG_SCF_FBW7_1

Location: 627:632

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 70.8833

COIL: 0.765

CONS_SCORE: 0.5383

DSS_SCORE: 0.3875

HELIX: 0.0838

FCONS_SCORE: 1.1486

RIG_SCORE: 0.7266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R635H	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ITPYQS	DEG_SCF_FBW7_1	0.25
p.R639H	SIDM00217	Colorectal Carcinoma	GDSC	ITPYQS	DEG_SCF_FBW7_1	0.1389
p.R639H	SIDM01617	Endometrial Carcinoma	GDSC	ITPYQS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	DEG_SCF_FBW7_1	627:632	ITPYQS	FBXW7	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons