DegronMD

Uniprot ID: P61218

Source protein: DNA-directed RNA polymerases I, II, and III subunit RPABC2

Source gene: POLR2F

Class: DEG_SCF_FBW7_1

Location: 52:58

E3 ligase: FBXW7

DEGRON score: 0.9874

ASA_SCORE: 54.8429

COIL: 0.8404

CONS_SCORE: 0.7283

DSS_SCORE: 0.4522

HELIX: 0.0443

FCONS_SCORE: 1.1683

RIG_SCORE: 0.8007

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A47V	TCGA-CK-4951	COAD	TCGA	ITTPYMT	DEG_SCF_FBW7_1	0.1944
p.V65M	TCGA-CM-6162	COAD	TCGA	ITTPYMT	DEG_SCF_FBW7_1	0.1389
p.V65M	SIDM01561	Melanoma	GDSC	ITTPYMT	DEG_SCF_FBW7_1	0.1389
p.V65M	ACH-000799	Skin Cancer	CCLE	ITTPYMT	DEG_SCF_FBW7_1	0.1389
p.P55L	TCGA-DA-A1HV	SKCM	TCGA	ITTPYMT	DEG_SCF_FBW7_1	0.7582
p.R64C	TCGA-DM-A288	COAD	TCGA	ITTPYMT	DEG_SCF_FBW7_1	0.1667
p.I52M	TCGA-GL-8500	KIRP	TCGA	ITTPYMT	DEG_SCF_FBW7_1	0.6507
p.R64Q	DO2443	BRCA	ICGC	ITTPYMT	DEG_SCF_FBW7_1	0.1667
p.R59C	DO9290	COAD	ICGC	ITTPYMT	DEG_SCF_FBW7_1	0.75
p.P67S	DO10582	COAD	ICGC	ITTPYMT	DEG_SCF_FBW7_1	0.0833
p.V60M	DO8479	COAD	ICGC	ITTPYMT	DEG_SCF_FBW7_1	0.2778
p.R57Q	DO234188	ESAD	ICGC	ITTPYMT	DEG_SCF_FBW7_1	0.7329
p.L61V	DO27468	LUSC	ICGC	ITTPYMT	DEG_SCF_FBW7_1	0.25
p.S56L	DO47368	SKCM	ICGC	ITTPYMT	DEG_SCF_FBW7_1	0.7667
p.S56L	DO43186	UCEC	ICGC	ITTPYMT	DEG_SCF_FBW7_1	0.7667
p.S59T	DO51277	SKCM	ICGC	ITTPYMT	DEG_SCF_FBW7_1	0.75
p.S59F	DO51277	SKCM	ICGC	ITTPYMT	DEG_SCF_FBW7_1	0.75
p.Y56H	SIDM02041	Colorectal Carcinoma	GDSC	ITTPYMT	DEG_SCF_FBW7_1	0.6118
p.T53I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ITTPYMT	DEG_SCF_FBW7_1	0.5966
p.R44Q	SIDM00974	Melanoma	GDSC	ITTPYMT	DEG_SCF_FBW7_1	0.1111
p.R44Q	WM35	skin	COSMIC	ITTPYMT	DEG_SCF_FBW7_1	0.1111
p.Y60N	SIDM00774	Breast Carcinoma	GDSC	ITTPYMT	DEG_SCF_FBW7_1	0.2778
p.Y60N	ACH-000691	Breast Cancer	CCLE	ITTPYMT	DEG_SCF_FBW7_1	0.2778
p.Y60N	HCC2157	breast	COSMIC	ITTPYMT	DEG_SCF_FBW7_1	0.2778
p.A63V	SIDM01766	Chondrosarcoma	GDSC	ITTPYMT	DEG_SCF_FBW7_1	0.1944
p.A63V	ACH-000418	Bone Cancer	CCLE	ITTPYMT	DEG_SCF_FBW7_1	0.1944
p.D64N	WM35	skin	COSMIC	ITTPYMT	DEG_SCF_FBW7_1	0.1667
p.Y55N	HCC2157	breast	COSMIC	ITTPYMT	DEG_SCF_FBW7_1	0.7059

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61218	DNA-directed RNA polymerases I, II, and III subunit RPABC2	DEG_SCF_FBW7_1	52:58	ITTPYMT	FBXW7	0.9874	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITTPYMT

Degron related mutations and impact score

Drug responses associated with POLR2F mutations

All proteins holding degron of ITTPYMT