DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ITTTPFAT
Uniprot ID:
Q2M2H8
Source protein:
Probable maltase-glucoamylase 2
Source gene:
MGAM2
Class:
DEG_SCF_FBW7_1
Location:
1979:1986
E3 ligase:
FBXW7
DEGRON score:
0.6791
ASA_SCORE:
75.1
COIL:
0.6498
CONS_SCORE:
0
DSS_SCORE:
0.4161
HELIX:
0.0185
FCONS_SCORE:
0
RIG_SCORE:
0.8033
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MGAM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ITTTPFAT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SCF_FBW7_1
1979:1986
ITTTPFAT
FBXW7
0.6791
More...