DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
ITTTPSPT
Uniprot ID:
Q2M2H8
Source protein:
Probable maltase-glucoamylase 2
Source gene:
MGAM2
Class:
DEG_SCF_FBW7_1
Location:
2060:2067
E3 ligase:
FBXW7
DEGRON score:
0.8005
ASA_SCORE:
83.45
COIL:
0.89
CONS_SCORE:
0
DSS_SCORE:
0.6213
HELIX:
0.0173
FCONS_SCORE:
0
RIG_SCORE:
0.6646
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MGAM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ITTTPSPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SCF_FBW7_1
2060:2067
ITTTPSPT
FBXW7
0.8005
More...