DegronMD

Uniprot ID: Q9HC56

Source protein: Protocadherin-9

Source gene: PCDH9

Class: DEG_SCF_FBW7_2

Location: 192:199

E3 ligase: FBXW7

DEGRON score: 0.8906

ASA_SCORE: 76.2625

COIL: 0.5891

CONS_SCORE: 0.4953

DSS_SCORE: 0.3611

HELIX: 0.0059

FCONS_SCORE: 0.9358

RIG_SCORE: 0.7894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L190Q	TCGA-A5-A0R8	UCEC	TCGA	IVETPEGE	DEG_SCF_FBW7_2	0.2778
p.L190Q	DO42584	UCEC	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.2778
p.T195P	TCGA-AA-3715	COAD	TCGA	IVETPEGE	DEG_SCF_FBW7_2	0.7031
p.T195P	DO8018	COAD	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.7031
p.N209D	TCGA-AZ-4315	COAD	TCGA	IVETPEGE	DEG_SCF_FBW7_2	0.0556
p.N209D	DO8842	COAD	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.0556
p.V193M	TCGA-IB-7651	PAAD	TCGA	IVETPEGE	DEG_SCF_FBW7_2	0.6097
p.V193M	DO46657	PAAD	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.6097
p.E197Q	TCGA-K4-A54R	BLCA	TCGA	IVETPEGE	DEG_SCF_FBW7_2	0.5633
p.E197Q	DO48611	BLCA	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.5633
p.Q208P	TCGA-UY-A9PE	BLCA	TCGA	IVETPEGE	DEG_SCF_FBW7_2	0.0833
p.Q208P	DO219043	BLCA	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.0833
p.S186R	TCGA-VQ-AA6J	STAD	TCGA	IVETPEGE	DEG_SCF_FBW7_2	0.1667
p.S186R	DO51802	STAD	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.1667
p.Q185H	TCGA-XX-A89A	BRCA	TCGA	IVETPEGE	DEG_SCF_FBW7_2	0.1389
p.Q185H	DO51229	BRCA	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.1389
p.L204P	DO225076	BRCA	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.1944
p.T195N	DO228476	GACA	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.7055
p.G184R	DO229459	SKCA	ICGC	IVETPEGE	DEG_SCF_FBW7_2	0.1111
p.G189R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	IVETPEGE	DEG_SCF_FBW7_2	0.25
p.G189R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	IVETPEGE	DEG_SCF_FBW7_2	0.25
p.S186T	SIDM00971	Breast Carcinoma	GDSC	IVETPEGE	DEG_SCF_FBW7_2	0.1667
p.S186T	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	IVETPEGE	DEG_SCF_FBW7_2	0.1667
p.G184W	ACH-001559	Lung Cancer	CCLE	IVETPEGE	DEG_SCF_FBW7_2	0.1111
p.N209S	ACH-001960	Bile Duct Cancer	CCLE	IVETPEGE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC56	Protocadherin-9	DEG_SCF_FBW7_2	192:199	IVETPEGE	FBXW7	0.8906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons