DegronMD

Uniprot ID: O60885

Source protein: Bromodomain-containing protein 4

Source gene: BRD4

Class: DEG_SCF_FBW7_1

Location: 233:240

E3 ligase: FBXW7

DEGRON score: 0.7082

ASA_SCORE: 97.425

COIL: 0.9229

CONS_SCORE: 0.2932

DSS_SCORE: 0.5425

HELIX: 0.0273

FCONS_SCORE: 1.0212

RIG_SCORE: 0.7378

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I233N	TCGA-CZ-5453	KIRC	TCGA	IVQTPVMT	DEG_SCF_FBW7_1	0.728
p.I233N	DO18016	KIRC	ICGC	IVQTPVMT	DEG_SCF_FBW7_1	0.728
p.P226L	TCGA-GF-A3OT	SKCM	TCGA	IVQTPVMT	DEG_SCF_FBW7_1	0.1389
p.P226L	DO47288	SKCM	ICGC	IVQTPVMT	DEG_SCF_FBW7_1	0.1389
p.V234I	TCGA-L5-A4OI	ESCA	TCGA	IVQTPVMT	DEG_SCF_FBW7_1	0.5965
p.H223P	DO48400	BLCA	ICGC	IVQTPVMT	DEG_SCF_FBW7_1	0.0556
p.H223Q	DO228974	LICA	ICGC	IVQTPVMT	DEG_SCF_FBW7_1	0.0556
p.P226T	DO229019	LICA	ICGC	IVQTPVMT	DEG_SCF_FBW7_1	0.1389
p.H223Y	DO46394	OV	ICGC	IVQTPVMT	DEG_SCF_FBW7_1	0.0556
p.V228I	DO229542	UTCA	ICGC	IVQTPVMT	DEG_SCF_FBW7_1	0.1944
p.Q245R	SIDM01617	Endometrial Carcinoma	GDSC	IVQTPVMT	DEG_SCF_FBW7_1	0.1944
p.Q245R	ACH-000994	Endometrial/Uterine Cancer	CCLE	IVQTPVMT	DEG_SCF_FBW7_1	0.1944

Drug responses associated with BRD4 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	JQ1	1.4304
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	I-BET-762	16.4678
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	JQ1	8.5878
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	PFI-1	4.3218
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	I-BET-762	1.0934
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	RVX-208	21.139
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	OTX015	0.1709
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	AZD5153	0.0375
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	JQ1	0.8175
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	I-BET-762	27.3861
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	JQ1	7.2794
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	PFI-1	14.8859
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	I-BET-762	5.2898
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	RVX-208	12.449
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	OTX015	0.925
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	AZD5153	0.2526
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	JQ1	0.8175
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	I-BET-762	27.3861
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	JQ1	7.2794
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	PFI-1	14.8859
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	I-BET-762	5.2898
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	RVX-208	12.449
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	OTX015	0.925
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	AZD5153	0.2526
SIDM00678	BLCA\|bladder	p.R1097H (No)	GDSC	JQ1	4.6801
SIDM00678	BLCA\|bladder	p.R1097H (No)	GDSC	I-BET-762	440.2382
SIDM00678	BLCA\|bladder	p.R1097H (No)	GDSC	JQ1	13.1181
SIDM00678	BLCA\|bladder	p.R1097H (No)	GDSC	PFI-1	27.0273
SIDM00678	BLCA\|bladder	p.R1097H (No)	GDSC	AZD5153	31.728
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	I-BET-762	1.0363
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	JQ1	0.1575
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	PFI-1	1.6233
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	I-BET-762	1.8903
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	RVX-208	24.341
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	OTX015	0.4102
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	AZD5153	1.2278
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	JQ1	2.3644
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	I-BET-762	15.0909
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	JQ1	0.3551
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	PFI-1	5.7264
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	I-BET-762	14.96
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	RVX-208	135.63
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	OTX015	12.366
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	AZD5153	11.404
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	JQ1	2.3644
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	I-BET-762	15.0909
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	JQ1	0.3551
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	PFI-1	5.7264
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	I-BET-762	14.96
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	RVX-208	135.63
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	OTX015	12.366
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	AZD5153	11.404
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	JQ1	2.3644
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	I-BET-762	15.0909
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	JQ1	0.3551
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	PFI-1	5.7264
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	I-BET-762	14.96
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	RVX-208	135.63
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	OTX015	12.366
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	AZD5153	11.404
SIDM01187	BRCA\|breast	p.T573K (No)	GDSC	JQ1	46.1862
SIDM01187	BRCA\|breast	p.T573K (No)	GDSC	I-BET-762	44.0666
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	JQ1	0.486
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	I-BET-762	3.3856
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	JQ1	12.5115
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	PFI-1	7.7487
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	I-BET-762	2.3254
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	RVX-208	35.167
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	OTX015	0.5221
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	AZD5153	0.1152
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	JQ1	0.1636
SIDM00382	GBM\|glioma	p.R1097H (No)	GDSC	JQ1	1.8762
SIDM00382	GBM\|glioma	p.R1097H (No)	GDSC	I-BET-762	72.9243
SIDM00382	GBM\|glioma	p.R1097H (No)	GDSC	JQ1	12.3412
SIDM00382	GBM\|glioma	p.R1097H (No)	GDSC	PFI-1	7.0555
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	JQ1	1.1252
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	I-BET-762	21.0327
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	JQ1	10.556
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	PFI-1	5.674
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	I-BET-762	10.246
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	RVX-208	43.409
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	OTX015	3.6348
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	AZD5153	3.4419
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	JQ1	14.9969
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	I-BET-762	24.4638
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	JQ1	11.628
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	PFI-1	16.9266
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	I-BET-762	159.69
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	RVX-208	176.48
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	OTX015	118.89
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	AZD5153	74.709
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	JQ1	0.2285
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	I-BET-762	0.7772
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	JQ1	8.5734
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	PFI-1	4.8298
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	I-BET-762	1.1894
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	RVX-208	21.578
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	OTX015	0.3864
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	AZD5153	0.0865
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	JQ1	2.6614
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	I-BET-762	287.9299
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	JQ1	9.75
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	PFI-1	8.4811
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	I-BET-762	85.054
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	RVX-208	32.519
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	OTX015	116.85
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	AZD5153	64.63
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	JQ1	2.835
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	I-BET-762	16.8114
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	JQ1	9.5904
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	PFI-1	11.8791
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	I-BET-762	5.5043
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	RVX-208	89.483
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	OTX015	1.3938
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	AZD5153	0.8312
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	JQ1	1.0699
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	I-BET-762	109.7817
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	JQ1	0.7416
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	PFI-1	6.4733
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	I-BET-762	32.878
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	RVX-208	140.09
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	OTX015	24.927
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	AZD5153	16.611
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	JQ1	2.3663
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	I-BET-762	26.2766
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	JQ1	10.9592
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	PFI-1	19.6215
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	I-BET-762	41.267
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	RVX-208	75.332
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	OTX015	9.0252
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	AZD5153	1.8821
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	JQ1	0.0517
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	I-BET-762	518.9565
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	I-BET-762	193.5
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	RVX-208	1241.2
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	OTX015	53.748
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	AZD5153	34.048
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	JQ1	1.3527
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	I-BET-762	49.241
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	JQ1	4.1244
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	PFI-1	12.8243
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	I-BET-762	18.035
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	RVX-208	129.34
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	OTX015	15.295
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	AZD5153	5.1788
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	JQ1	0.8268
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	I-BET-762	9.1981
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	JQ1	0.7352
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	PFI-1	6.6406
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	I-BET-762	23.931
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	RVX-208	44.067
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	OTX015	16.318
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	AZD5153	0.0909
SIDM00938	BRCA\|breast	p.Q36* (No)	GDSC	JQ1	0.8091
SIDM00938	BRCA\|breast	p.Q36* (No)	GDSC	I-BET-762	20.4407
SIDM00938	BRCA\|breast	p.Q36* (No)	GDSC	JQ1	0.314
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	JQ1	0.0493
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	I-BET-762	2.4104
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	JQ1	8.8018
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	PFI-1	2.5282
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	I-BET-762	5.359
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	RVX-208	64.165
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	OTX015	2.1001
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	AZD5153	1.5437
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	JQ1	0.0493
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	I-BET-762	2.4104
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	JQ1	8.8018
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	PFI-1	2.5282
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	I-BET-762	5.359
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	RVX-208	64.165
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	OTX015	2.1001
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	AZD5153	1.5437
SIDM00995	UNCLASSIFIED\|skin_other	p.E1113delE (No)	GDSC	JQ1	0.2961
SIDM00995	UNCLASSIFIED\|skin_other	p.E1113delE (No)	GDSC	I-BET-762	161.8689
SIDM00995	UNCLASSIFIED\|skin_other	p.E1113delE (No)	GDSC	JQ1	5.5725
SIDM00995	UNCLASSIFIED\|skin_other	p.E1113delE (No)	GDSC	PFI-1	16.0319
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	JQ1	0.6656
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	I-BET-762	66.2157
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	JQ1	13.2829
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	PFI-1	25.092
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	I-BET-762	55.201
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	RVX-208	440.59
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	OTX015	17.675
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	AZD5153	6.0611
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	JQ1	0.3976
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	I-BET-762	1.2888
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	JQ1	7.6954
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	PFI-1	5.9755
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	I-BET-762	5.6449
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	RVX-208	32.934
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	OTX015	1.3879
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	AZD5153	0.3857
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	JQ1	0.4262
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	I-BET-762	195.2428
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	JQ1	10.3097
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	PFI-1	10.4331
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	I-BET-762	39.801
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	RVX-208	62.179
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	OTX015	22.454
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	AZD5153	42.735
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	JQ1	0.2974
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	I-BET-762	61.3936
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	JQ1	1.0951
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	PFI-1	10.2788
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	I-BET-762	16.979
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	RVX-208	96.503
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	OTX015	21.915
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	AZD5153	6.4125
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	JQ1	0.2974
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	I-BET-762	61.3936
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	JQ1	1.0951
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	PFI-1	10.2788
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	I-BET-762	16.979
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	RVX-208	96.503
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	OTX015	21.915
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	AZD5153	6.4125
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	I-BET-762	20.859
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	JQ1	5.699
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	PFI-1	49.0441
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	I-BET-762	45.177
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	RVX-208	316.56
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	OTX015	13.116
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	AZD5153	14.469
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	I-BET-762	20.859
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	JQ1	5.699
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	PFI-1	49.0441
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	I-BET-762	45.177
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	RVX-208	316.56
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	OTX015	13.116
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	AZD5153	14.469
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	I-BET-762	20.859
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	JQ1	5.699
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	PFI-1	49.0441
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	I-BET-762	45.177
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	RVX-208	316.56
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	OTX015	13.116
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	AZD5153	14.469
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	JQ1	51.5138
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	I-BET-762	182.0816
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	JQ1	12.4468
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	PFI-1	28.3601
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	I-BET-762	20.848
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	RVX-208	164.62
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	OTX015	21.788
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	AZD5153	12.574
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	JQ1	2.6614
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	I-BET-762	287.9299
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	JQ1	9.75
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	PFI-1	8.4811
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	I-BET-762	85.054
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	RVX-208	32.519
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	OTX015	116.85
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	AZD5153	64.63
SIDM00216	COREAD\|large_intestine	p.A1203T (No)	GDSC	I-BET-762	2.1779
SIDM00216	COREAD\|large_intestine	p.A1203T (No)	GDSC	I-BET-762	6.6864
SIDM00216	COREAD\|large_intestine	p.A1203T (No)	GDSC	RVX-208	34.972
SIDM00216	COREAD\|large_intestine	p.A1203T (No)	GDSC	OTX015	5.0449
SIDM00216	COREAD\|large_intestine	p.A1203T (No)	GDSC	AZD5153	1.5589
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	JQ1	0.6889
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	I-BET-762	22.1191
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	JQ1	14.8593
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	PFI-1	76.6459
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	I-BET-762	6.6596
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	RVX-208	67.087
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	OTX015	4.79
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	AZD5153	294.27
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	PFI-1	9.8795
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	RVX-208	292.38
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	OTX015	7.248
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	AZD5153	0.7983
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	PFI-1	9.8795
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	RVX-208	292.38
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	OTX015	7.248
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	AZD5153	0.7983
SIDM00660	COREAD\|large_intestine	p.Q235* (Yes)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.Q235* (Yes)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.Q235* (Yes)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.Q235* (Yes)	GDSC	PFI-1	9.8795
SIDM00660	COREAD\|large_intestine	p.Q235* (Yes)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.Q235* (Yes)	GDSC	RVX-208	292.38
SIDM00660	COREAD\|large_intestine	p.Q235* (Yes)	GDSC	OTX015	7.248
SIDM00660	COREAD\|large_intestine	p.Q235* (Yes)	GDSC	AZD5153	0.7983
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	JQ1	1.8098
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	I-BET-762	502.0155
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	JQ1	7.4455
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	PFI-1	24.1874
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	I-BET-762	29.78
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	RVX-208	240.46
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	OTX015	5.4922
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	AZD5153	3.427
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	JQ1	0.7048
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	I-BET-762	11.9188
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	JQ1	3.934
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	PFI-1	3.5241
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	I-BET-762	2.8854
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	RVX-208	19.105
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	OTX015	0.7025
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	AZD5153	0.1013
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	JQ1	2.499
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	I-BET-762	161.1834
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	JQ1	0.6553
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	I-BET-762	36.6547
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	JQ1	9.5459
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	PFI-1	12.5944
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	I-BET-762	67.938
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	RVX-208	155.56
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	OTX015	21.154
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	AZD5153	29.575
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	JQ1	0.3959
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	I-BET-762	26.4252
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	JQ1	9.7441
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	PFI-1	23.2999
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	I-BET-762	278.72
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	RVX-208	332.33
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	OTX015	96.088
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	AZD5153	26.265
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	JQ1	0.3654
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	I-BET-762	76.3613
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	JQ1	14.2422
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	PFI-1	137.6001
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	I-BET-762	8.0329
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	RVX-208	75.058
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	OTX015	1.163
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	AZD5153	0.28
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	JQ1	0.3654
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	I-BET-762	76.3613
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	JQ1	14.2422
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	PFI-1	137.6001
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	I-BET-762	8.0329
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	RVX-208	75.058
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	OTX015	1.163
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	AZD5153	0.28
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	JQ1	0.3654
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	I-BET-762	76.3613
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	JQ1	14.2422
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	PFI-1	137.6001
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	I-BET-762	8.0329
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	RVX-208	75.058
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	OTX015	1.163
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	AZD5153	0.28
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.G182delG (No)	GDSC	JQ1	0.9321
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.G182delG (No)	GDSC	I-BET-762	271.4943
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.G182delG (No)	GDSC	JQ1	7.6527
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.G182delG (No)	GDSC	PFI-1	21.7859
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	JQ1	0.5633
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	I-BET-762	69.2874
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	JQ1	8.5171
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	PFI-1	16.4545
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	I-BET-762	51.757
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	RVX-208	59.165
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	OTX015	9.2643
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	AZD5153	2.7127
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	JQ1	37.01
SIDM00545	SKCM\|melanoma	p.P784L (No)	GDSC	JQ1	19.0047
SIDM00545	SKCM\|melanoma	p.P784L (No)	GDSC	I-BET-762	237.53
SIDM00545	SKCM\|melanoma	p.P784L (No)	GDSC	JQ1	16.7562
SIDM00545	SKCM\|melanoma	p.P784L (No)	GDSC	PFI-1	12.3569
SIDM00545	SKCM\|melanoma	p.K629* (No)	GDSC	JQ1	19.0047
SIDM00545	SKCM\|melanoma	p.K629* (No)	GDSC	I-BET-762	237.53
SIDM00545	SKCM\|melanoma	p.K629* (No)	GDSC	JQ1	16.7562
SIDM00545	SKCM\|melanoma	p.K629* (No)	GDSC	PFI-1	12.3569
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	JQ1	0.0889
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	I-BET-762	5.2154
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	JQ1	19.3529
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	PFI-1	7.8456
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	I-BET-762	9.5466
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	RVX-208	67.743
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	OTX015	8.3357
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	AZD5153	1.3243
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	JQ1	0.2855
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	I-BET-762	1.5369
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	JQ1	8.8691
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	PFI-1	19.8375
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	I-BET-762	7.1915
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	RVX-208	100.95
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	OTX015	2.3039
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	AZD5153	0.6171
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	JQ1	2.9811
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	I-BET-762	125.1316
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	JQ1	16.5418
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	PFI-1	18.1302
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	I-BET-762	343.28
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	RVX-208	1051.7
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	OTX015	57.453
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	AZD5153	40.25
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	JQ1	66.5135
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	I-BET-762	218.0698
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	JQ1	18.3066
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	PFI-1	27.7498
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	I-BET-762	95.138
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	RVX-208	556.97
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	OTX015	55.568
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	AZD5153	25.766
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	JQ1	1.6868
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	I-BET-762	31.4723
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	JQ1	10.2008
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	PFI-1	52.0761
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	I-BET-762	61.918
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	RVX-208	159.98
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	OTX015	15.271
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	AZD5153	4.8882
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	JQ1	0.1377
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	I-BET-762	0.5177
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	JQ1	6.965
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	PFI-1	4.9932
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	I-BET-762	0.9391
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	RVX-208	12.926
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	OTX015	0.2456
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	AZD5153	0.042
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	JQ1	1.1252
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	I-BET-762	21.0327
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	JQ1	10.556
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	PFI-1	5.674
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	I-BET-762	10.246
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	RVX-208	43.409
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	OTX015	3.6348
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	AZD5153	3.4419
SIDM00281	UNCLASSIFIED\|skin_other	p.S579delS (No)	GDSC	JQ1	1.4281
SIDM00281	UNCLASSIFIED\|skin_other	p.S579delS (No)	GDSC	I-BET-762	212.5266
SIDM00115	HNSC\|head_and_neck	p.D301A (No)	GDSC	JQ1	0.162
SIDM00115	HNSC\|head_and_neck	p.D301A (No)	GDSC	I-BET-762	7.2574
SIDM00115	HNSC\|head_and_neck	p.D301A (No)	GDSC	JQ1	9.8403
SIDM00115	HNSC\|head_and_neck	p.D301A (No)	GDSC	PFI-1	15.2396
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	JQ1	0.9581
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	I-BET-762	95.874
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	JQ1	9.4882
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	PFI-1	6.1114
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	I-BET-762	11.965
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	RVX-208	50.401
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	OTX015	3.7042
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	AZD5153	0.8672
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	I-BET-762	14.4292
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	JQ1	12.5677
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	PFI-1	7.3447
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	I-BET-762	28.003
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	RVX-208	107.19
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	OTX015	27.715
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	AZD5153	3.7453

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IVQTPVMT

Degron related mutations and impact score

Drug responses associated with BRD4 mutations

All proteins holding degron of IVQTPVMT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60885	Bromodomain-containing protein 4	DEG_SCF_FBW7_1	233:240	IVQTPVMT	FBXW7	0.7082	More...