DegronMD

Uniprot ID: P57682

Source protein: Krueppel-like factor 3

Source gene: KLF3

Class: DEG_SCF_FBW7_2

Location: 37:44

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 71.1

COIL: 0.7186

CONS_SCORE: 0.4478

DSS_SCORE: 0.3175

HELIX: 0.0791

FCONS_SCORE: 0.9933

RIG_SCORE: 0.7802

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E44K	TCGA-B6-A0IK	BRCA	TCGA	IYSTPLPE	DEG_SCF_FBW7_2	0.7022
p.E44K	DO1902	BRCA	ICGC	IYSTPLPE	DEG_SCF_FBW7_2	0.7022
p.G52D	TCGA-DU-6392	LGG	TCGA	IYSTPLPE	DEG_SCF_FBW7_2	0.1111
p.G52D	DO22237	LGG	ICGC	IYSTPLPE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P57682	Krueppel-like factor 3	DEG_SCF_FBW7_2	37:44	IYSTPLPE	FBXW7	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons