DegronMD

Uniprot ID: Q9NR48

Source protein: Histone-lysine N-methyltransferase ASH1L

Source gene: ASH1L

Class: LIG_APCC_ABBAyCdc20_2

Location: 1991:1997

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9738

ASA_SCORE: 57.3571

COIL: 0.5984

CONS_SCORE: 0.5275

DSS_SCORE: 0.5358

HELIX: 0.1484

FCONS_SCORE: 1.2922

RIG_SCORE: 0.7199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1981L	TCGA-A5-A0G2	UCEC	TCGA	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P1981L	DO41235	UCEC	ICGC	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1983C	TCGA-A5-A1OF	UCEC	TCGA	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1983C	DO42568	UCEC	ICGC	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R2007Q	TCGA-BT-A3PH	BLCA	TCGA	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R2007Q	DO856	BLCA	ICGC	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1983H	TCGA-CV-A6K1	HNSC	TCGA	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1983H	DO52078	HNSC	ICGC	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1983H	DO231906	LINC	ICGC	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.V1998I	DO23088	LINC	ICGC	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A1992E	DO50692	ORCA	ICGC	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.659
p.P1981S	SIDM00386	Ewing's Sarcoma	GDSC	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P1981S	ACH-000391	Bone Cancer	CCLE	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P1981S	MHH-ES-1	bone	COSMIC	KAGLYSD	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR48	Histone-lysine N-methyltransferase ASH1L	LIG_APCC_ABBAyCdc20_2	1991:1997	KAGLYSD	APC,CDC20,FZR1	0.9738	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons