DegronMD

Uniprot ID: P40189

Source protein: Interleukin-6 receptor subunit beta

Source gene: IL6ST

Class: LIG_APCC_ABBAyCdc20_2

Location: 679:685

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7426

ASA_SCORE: 93.3

COIL: 0.7139

CONS_SCORE: 0.4213

DSS_SCORE: 0.5253

HELIX: 0.1886

FCONS_SCORE: 0.8414

RIG_SCORE: 0.6726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H669L	TCGA-55-8616	LUAD	TCGA	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.N677I	TCGA-A4-A5DU	KIRP	TCGA	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q681K	TCGA-A5-A0G2	UCEC	TCGA	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.5833
p.E695K	TCGA-ZF-AA53	BLCA	TCGA	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E695K	DO219096	BLCA	ICGC	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.S671L	DO48547	STAD	ICGC	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.S671L	IM-95	stomach	COSMIC	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.N675S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.N675S	ACH-002059	Leukemia	CCLE	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.N675S	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T689I	SIDM00837	Colorectal Carcinoma	GDSC	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T689I	ACH-000958	Colon/Colorectal Cancer	CCLE	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T689I	SW48	large_intestine	COSMIC	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S688P	SW13	adrenal_gland	COSMIC	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.25
p.G669R	JHOS-3	ovary	COSMIC	KDQMYSD	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40189	Interleukin-6 receptor subunit beta	LIG_APCC_ABBAyCdc20_2	679:685	KDQMYSD	APC,CDC20,FZR1	0.7426	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons