DegronMD

Uniprot ID: Q9UPV0

Source protein: Centrosomal protein of 164 kDa

Source gene: CEP164

Class: LIG_APCC_ABBAyCdc20_2

Location: 1086:1092

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.906

ASA_SCORE: 108.9571

COIL: 0.5329

CONS_SCORE: 0.7127

DSS_SCORE: 0.2837

HELIX: 0.4394

FCONS_SCORE: 1.0952

RIG_SCORE: 0.7703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1086R	TCGA-66-2768	LUSC	TCGA	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.6126
p.K1086R	DO27216	LUSC	ICGC	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.6126
p.D1088E	TCGA-AP-A0LM	UCEC	TCGA	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.5647
p.D1088E	DO43306	UCEC	ICGC	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.5647
p.E1077D	TCGA-AX-A2HC	UCEC	TCGA	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E1077D	DO41572	UCEC	ICGC	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V1099G	TCGA-BG-A222	UCEC	TCGA	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V1099G	DO42977	UCEC	ICGC	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.L1091V	TCGA-BR-7851	STAD	TCGA	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.5654
p.L1091V	DO38711	STAD	ICGC	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.5654
p.S1093I	TCGA-FI-A2D5	UCEC	TCGA	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S1093I	DO41331	UCEC	ICGC	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S1096F	SIDM00924	Other Solid Cancers	GDSC	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S1096F	ACH-000867	Lung Cancer	CCLE	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S1096F	ChaGo-K-1	lung	COSMIC	KEDLYLD	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPV0	Centrosomal protein of 164 kDa	LIG_APCC_ABBAyCdc20_2	1086:1092	KEDLYLD	APC,CDC20,FZR1	0.906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons