DegronMD

Uniprot ID: Q8TEQ6

Source protein: Gem-associated protein 5

Source gene: GEMIN5

Class: LIG_APCC_ABBAyCdc20_2

Location: 860:866

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8167

ASA_SCORE: 71.3714

COIL: 0.3299

CONS_SCORE: 0.5169

DSS_SCORE: 0.334

HELIX: 0.5853

FCONS_SCORE: 1.0344

RIG_SCORE: 0.752

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V869A	TCGA-AJ-A3EK	UCEC	TCGA	KEELHQD	LIG_APCC_ABBAyCdc20_2	0.25
p.V869A	DO41584	UCEC	ICGC	KEELHQD	LIG_APCC_ABBAyCdc20_2	0.25
p.E861V	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	KEELHQD	LIG_APCC_ABBAyCdc20_2	0.6582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEQ6	Gem-associated protein 5	LIG_APCC_ABBAyCdc20_2	860:866	KEELHQD	APC,CDC20,FZR1	0.8167	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons