DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
KGPVYHE
Uniprot ID:
Q7Z4H8
Source protein:
Protein O-glucosyltransferase 3
Source gene:
POGLUT3
Class:
LIG_APCC_ABBAyCdc20_2
Location:
133:139
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7055
ASA_SCORE:
77.5571
COIL:
0.726
CONS_SCORE:
0.3209
DSS_SCORE:
0.1657
HELIX:
0.0654
FCONS_SCORE:
0.9069
RIG_SCORE:
0.7906
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y130H
SIDM01409
Bladder Carcinoma
GDSC
KGPVYHE
LIG_APCC_ABBAyCdc20_2
0.25
Drug responses associated with POGLUT3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KGPVYHE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z4H8
Protein O-glucosyltransferase 3
LIG_APCC_ABBAyCdc20_2
133:139
KGPVYHE
APC,CDC20,FZR1
0.7055
More...