DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KIPLYEE
Uniprot ID:
Q86YA3
Source protein:
Protein ZGRF1
Source gene:
ZGRF1
Class:
LIG_APCC_ABBAyCdc20_2
Location:
1421:1427
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6095
ASA_SCORE:
62.0571
COIL:
0.6183
CONS_SCORE:
0
DSS_SCORE:
0.051
HELIX:
0.003
FCONS_SCORE:
0
RIG_SCORE:
0.8881
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ZGRF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KIPLYEE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86YA3
Protein ZGRF1
LIG_APCC_ABBAyCdc20_2
1421:1427
KIPLYEE
APC,CDC20,FZR1
0.6095
More...