DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
KIRIFPE
Uniprot ID:
Q8IXT1
Source protein:
DNA damage-induced apoptosis suppressor protein
Source gene:
DDIAS
Class:
LIG_APCC_ABBAyCdc20_2
Location:
807:813
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6704
ASA_SCORE:
98.4143
COIL:
0.6929
CONS_SCORE:
0.439
DSS_SCORE:
0.4874
HELIX:
0.1203
FCONS_SCORE:
0.9775
RIG_SCORE:
0.8194
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DDIAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KIRIFPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IXT1
DNA damage-induced apoptosis suppressor protein
LIG_APCC_ABBAyCdc20_2
807:813
KIRIFPE
APC,CDC20,FZR1
0.6704
More...