DegronMD

Uniprot ID: Q8NEU8

Source protein: DCC-interacting protein 13-beta

Source gene: APPL2

Class: DEG_APCC_KENBOX_2

Location: 153:157

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5825

ASA_SCORE: 116.42

COIL: 0.5738

CONS_SCORE: 0.7267

DSS_SCORE: 0.4903

HELIX: 0.4216

FCONS_SCORE: 1.0901

RIG_SCORE: 0.6871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y153C	TCGA-FI-A2D5	UCEC	TCGA	KKENE	DEG_APCC_KENBOX_2	0.7087
p.G163E	DO457	BLCA	ICGC	KKENE	DEG_APCC_KENBOX_2	0.1667
p.M157L	DO45460	LUSC	ICGC	KKENE	DEG_APCC_KENBOX_2	0.711
p.P157H	SIDM00789	Colorectal Carcinoma	GDSC	KKENE	DEG_APCC_KENBOX_2	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEU8	DCC-interacting protein 13-beta	DEG_APCC_KENBOX_2	153:157	KKENE	APC,CDC20,FZR1	0.5825	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons