DegronMD

Uniprot ID: O94885

Source protein: SAM and SH3 domain-containing protein 1

Source gene: SASH1

Class: LIG_APCC_ABBAyCdc20_2

Location: 312:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8791

ASA_SCORE: 91.8

COIL: 0.7723

CONS_SCORE: 0.4065

DSS_SCORE: 0.543

HELIX: 0.064

FCONS_SCORE: 1.1282

RIG_SCORE: 0.7059

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y307C	TCGA-06-0188	GBM	TCGA	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.6389
p.Y307C	DO12658	GBM	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.6389
p.E326K	TCGA-19-5956	GBM	TCGA	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E326K	DO229003	COCA	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E326K	DO13863	GBM	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.S308C	TCGA-5P-A9KC	KIRP	TCGA	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S308C	DO223954	KIRP	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A305T	TCGA-AX-A2HC	UCEC	TCGA	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A305T	TCGA-B5-A0JY	UCEC	TCGA	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A305T	DO43041	UCEC	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A305T	DO41572	UCEC	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A305T	SIDM01609	Endometrial Carcinoma	GDSC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A305T	ACH-000972	Endometrial/Uterine Cancer	CCLE	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R303L	TCGA-B5-A0K6	UCEC	TCGA	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R303L	DO40808	UCEC	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P321L	TCGA-CV-7568	HNSC	TCGA	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.25
p.P321L	DO14160	HNSC	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.25
p.L306I	TCGA-DA-A1IB	SKCM	TCGA	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.L306I	DO38033	SKCM	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.V310M	TCGA-EO-A3KX	UCEC	TCGA	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V310M	DO219774	UCEC	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V310M	SIDM00251	Gastric Carcinoma	GDSC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V310M	ACH-000145	Sarcoma	CCLE	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V310M	ACH-000949	Gastric Cancer	CCLE	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V310M	TGBC11TKB	stomach	COSMIC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P314S	TCGA-HF-A5NB	STAD	TCGA	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.5641
p.P314S	DO50127	STAD	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.5641
p.A305S	DO228971	LICA	ICGC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.F316Y	SIDM01265	Plasma Cell Myeloma	GDSC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.6417
p.F316Y	ACH-000763	Myeloma	CCLE	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.6417
p.F316Y	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.6417
p.E322K	SIDM01106	Melanoma	GDSC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E322K	ACH-000822	Skin Cancer	CCLE	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E322K	SK-MEL-24	skin	COSMIC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R303P	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R303P	SIDM00585	Hepatocellular Carcinoma	GDSC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R303P	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R303P	SIDM00162	Biliary Tract Carcinoma	GDSC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R309T	NB(TU)1-10	autonomic_ganglia	COSMIC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.25
p.T318A	Becker	central_nervous_system	COSMIC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.7139
p.A326T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A327T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	KKPLFFD	LIG_APCC_ABBAyCdc20_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKPLFFD

Degron related mutations and impact score

Drug responses associated with SASH1 mutations

All proteins holding degron of KKPLFFD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	LIG_APCC_ABBAyCdc20_2	312:318	KKPLFFD	APC,CDC20,FZR1	0.8791	More...