DegronMD

Uniprot ID: Q6TGC4

Source protein: Protein-arginine deiminase type-6

Source gene: PADI6

Class: LIG_APCC_ABBAyCdc20_2

Location: 178:184

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7025

ASA_SCORE: 82.0857

COIL: 0.5947

CONS_SCORE: 0.4872

DSS_SCORE: 0.2432

HELIX: 0.34

FCONS_SCORE: 1.2478

RIG_SCORE: 0.8659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T187M	SIDM00704	Small Cell Lung Carcinoma	GDSC	KKVIFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.T177A	SIDM00534	Colorectal Carcinoma	GDSC	KKVIFSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.I181F	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKVIFSE	LIG_APCC_ABBAyCdc20_2	0.7415

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6TGC4	Protein-arginine deiminase type-6	LIG_APCC_ABBAyCdc20_2	178:184	KKVIFSE	APC,CDC20,FZR1	0.7025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons