DegronMD

Uniprot ID: Q8TAQ5

Source protein: Zinc finger protein 420

Source gene: ZNF420

Class: LIG_APCC_ABBAyCdc20_2

Location: 4:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6204

ASA_SCORE: 98.3286

COIL: 0.6044

CONS_SCORE: 0.3894

DSS_SCORE: 0.2178

HELIX: 0.0036

FCONS_SCORE: 0.8539

RIG_SCORE: 0.8948

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F15L	TCGA-AJ-A3EK	UCEC	TCGA	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F15L	TCGA-EO-A22U	UCEC	TCGA	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F15L	DO10858	ESAD	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F15L	DO41584	UCEC	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F15L	DO43755	UCEC	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F15L	ACH-001081	Colon/Colorectal Cancer	CCLE	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F15L	HCC2998	large_intestine	COSMIC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R3W	TCGA-FR-A8YD	SKCM	TCGA	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R3W	DO50302	SKCM	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R3Q	TCGA-HU-A4GQ	STAD	TCGA	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R3Q	DO47767	STAD	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.3056
p.M7L	DO50348	ESAD	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.5999
p.D14N	DO50346	ESAD	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A12V	DO233918	GACA	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.M7I	DO229025	LICA	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.6507
p.M7I	SIDM00305	Ovarian Carcinoma	GDSC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.6507
p.M7I	ACH-000132	Ovarian Cancer	CCLE	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.6507
p.M7I	JHOS-2	ovary	COSMIC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.6507
p.Q17H	DO229008	LICA	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A2T	DO227933	PBCA	ICGC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E18K	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E18K	ACH-000824	Esophageal Cancer	CCLE	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E18K	KYSE-510	oesophagus	COSMIC	KLVMFRD	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAQ5	Zinc finger protein 420	LIG_APCC_ABBAyCdc20_2	4:10	KLVMFRD	APC,CDC20,FZR1	0.6204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons