DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
KPIAYVKPF
Uniprot ID:
P86496
Source protein:
Proline-rich protein 20A
Source gene:
PRR20A
Class:
DEG_SIAH_1
Location:
50:58
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.92
ASA_SCORE:
87.4222
COIL:
0.8251
CONS_SCORE:
0.8778
DSS_SCORE:
0.7104
HELIX:
0.0268
FCONS_SCORE:
1.0869
RIG_SCORE:
0.7043
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PRR20A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KPIAYVKPF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P86479
Proline-rich protein 20C
DEG_SIAH_1
50:58
KPIAYVKPF
SIAH1,SIAH2,SIAH3
0.92
More...
P86480
Proline-rich protein 20D
DEG_SIAH_1
50:58
KPIAYVKPF
SIAH1,SIAH2,SIAH3
0.92
More...
P86478
Proline-rich protein 20E
DEG_SIAH_1
50:58
KPIAYVKPF
SIAH1,SIAH2,SIAH3
0.92
More...
P86496
Proline-rich protein 20A
DEG_SIAH_1
50:58
KPIAYVKPF
SIAH1,SIAH2,SIAH3
0.92
More...
P86481
Proline-rich protein 20B
DEG_SIAH_1
50:58
KPIAYVKPF
SIAH1,SIAH2,SIAH3
0.92
More...