DegronMD

Uniprot ID: Q5JPB2

Source protein: Zinc finger protein 831

Source gene: ZNF831

Class: LIG_APCC_ABBAyCdc20_2

Location: 1462:1468

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6969

ASA_SCORE: 91.7571

COIL: 0.7713

CONS_SCORE: 0.5106

DSS_SCORE: 0.5145

HELIX: 0.0581

FCONS_SCORE: 1.0131

RIG_SCORE: 0.7684

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1477Y	TCGA-22-1016	LUSC	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S1477Y	DO26971	LUSC	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.I1465S	TCGA-A5-A1OF	UCEC	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.7341
p.I1465S	DO42568	UCEC	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.7341
p.A1452V	TCGA-AA-3952	COAD	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A1452V	DO10341	COAD	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.T1459S	TCGA-AP-A1DK	UCEC	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.T1459S	DO42033	UCEC	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.D1460Y	TCGA-AX-A05Z	UCEC	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D1460Y	DO40884	UCEC	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.K1478R	TCGA-B5-A1MX	UCEC	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.K1478R	DO41999	UCEC	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D1460E	TCGA-D1-A17Q	UCEC	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D1460E	DO41903	UCEC	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S1456L	TCGA-D3-A2J7	SKCM	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S1456L	DO47695	SKCM	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S1456L	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S1456L	ACH-000873	Esophageal Cancer	CCLE	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S1456L	KYSE-270	oesophagus	COSMIC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P1463S	TCGA-EO-A22U	UCEC	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.5641
p.P1463S	DO43755	UCEC	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.5641
p.S1467L	TCGA-FD-A3N6	BLCA	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.6556
p.S1467L	DO575	BLCA	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.6556
p.P1472S	TCGA-IB-7651	PAAD	TCGA	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P1472S	DO46657	PAAD	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.F1475I	DO233906	GACA	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q1470H	DO230950	LUSC	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q1470H	DO224638	LUSC	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V1457I	DO222578	MELA	ICGC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R1471K	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.R1471K	ACH-000379	Lung Cancer	CCLE	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.R1471K	NCI-H1781	lung	COSMIC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.A1452T	SIDM00878	Breast Carcinoma	GDSC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A1452T	ACH-000930	Breast Cancer	CCLE	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A1452T	HCC1569	breast	COSMIC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.S1453Y	SIDM01569	Hepatocellular Carcinoma	GDSC	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.K1478I	ACH-000436	Myeloma	CCLE	KPYIFSD	LIG_APCC_ABBAyCdc20_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KPYIFSD

Degron related mutations and impact score

Drug responses associated with ZNF831 mutations

All proteins holding degron of KPYIFSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JPB2	Zinc finger protein 831	LIG_APCC_ABBAyCdc20_2	1462:1468	KPYIFSD	APC,CDC20,FZR1	0.6969	More...