DegronMD

Uniprot ID: Q14586

Source protein: Zinc finger protein 267

Source gene: ZNF267

Class: LIG_APCC_ABBAyCdc20_2

Location: 312:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8144

ASA_SCORE: 88.5

COIL: 0.7429

CONS_SCORE: 0.6014

DSS_SCORE: 0.4447

HELIX: 0.0243

FCONS_SCORE: 1.0329

RIG_SCORE: 0.7491

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E318V	TCGA-63-5128	LUSC	TCGA	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.7693
p.E318V	DO27255	LUSC	ICGC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.7693
p.K302N	TCGA-86-8054	LUAD	TCGA	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.5
p.K302N	DO23923	LUAD	ICGC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.5
p.I315L	TCGA-AA-A010	COAD	TCGA	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.6063
p.E319D	TCGA-D1-A16X	UCEC	TCGA	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E319D	DO222884	COCA	ICGC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E319D	DO41799	UCEC	ICGC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D303N	TCGA-D8-A73U	BRCA	TCGA	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D303N	DO219629	BRCA	ICGC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E318Q	DO234267	ESAD	ICGC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.6744
p.G328W	DO228986	LICA	ICGC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I315M	DO219960	SARC	ICGC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.6507
p.L310I	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L310I	H3255	lung	COSMIC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K312E	SIDM00774	Breast Carcinoma	GDSC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.K312E	ACH-000691	Breast Cancer	CCLE	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.K312E	HCC2157	breast	COSMIC	KQIIHNE	LIG_APCC_ABBAyCdc20_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14586	Zinc finger protein 267	LIG_APCC_ABBAyCdc20_2	312:318	KQIIHNE	APC,CDC20,FZR1	0.8144	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons