DegronMD

Uniprot ID: Q9UJW8

Source protein: Zinc finger protein 180

Source gene: ZNF180

Class: LIG_APCC_ABBAyCdc20_2

Location: 125:131

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6422

ASA_SCORE: 106.3143

COIL: 0.5359

CONS_SCORE: 0.5718

DSS_SCORE: 0.5149

HELIX: 0.0511

FCONS_SCORE: 1.2155

RIG_SCORE: 0.7832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A134S	TCGA-EE-A29G	SKCM	TCGA	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.A116V	TCGA-IB-7651	PAAD	TCGA	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D118E	DO8722	COAD	ICGC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q139K	DO229031	LICA	ICGC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D133E	DO229034	LICA	ICGC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R130G	DO38563	STAD	ICGC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.7568
p.D133Y	DO41644	UCEC	ICGC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.D133Y	DO41331	UCEC	ICGC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.D137N	MZ7-mel	skin	COSMIC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P122S	22RV1	prostate	COSMIC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.K132E	NCI-H211	lung	COSMIC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P120S	22RV1	prostate	COSMIC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K134E	NCI-H211	lung	COSMIC	KQRIFDE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJW8	Zinc finger protein 180	LIG_APCC_ABBAyCdc20_2	125:131	KQRIFDE	APC,CDC20,FZR1	0.6422	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons