DegronMD

Uniprot ID: Q86YI8

Source protein: PHD finger protein 13

Source gene: PHF13

Class: LIG_APCC_ABBAyCdc20_2

Location: 205:211

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9133

ASA_SCORE: 106.3571

COIL: 0.728

CONS_SCORE: 0.3574

DSS_SCORE: 0.4947

HELIX: 0.0813

FCONS_SCORE: 0.9854

RIG_SCORE: 0.8077

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R210L	TCGA-37-5819	LUSC	TCGA	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.7316
p.R210L	DO26479	LUSC	ICGC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.7316
p.Q203H	TCGA-44-6774	LUAD	TCGA	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q203H	DO25000	LUAD	ICGC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R198W	TCGA-AX-A1C4	UCEC	TCGA	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R198W	DO222765	COCA	ICGC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R198W	DO42480	UCEC	ICGC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R210Q	TCGA-BR-4184	STAD	TCGA	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.6218
p.R210Q	TCGA-G5-6233	READ	TCGA	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.6218
p.R210Q	DO36626	READ	ICGC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.6218
p.R210Q	DO38328	STAD	ICGC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.6218
p.V201I	TCGA-DU-6392	LGG	TCGA	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V201I	DO222503	COCA	ICGC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V201I	DO22237	LGG	ICGC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E212D	TCGA-ER-A19P	SKCM	TCGA	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E212D	DO47623	SKCM	ICGC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S214N	DO228138	PBCA	ICGC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.25
p.R202Q	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.25
p.R202Q	ACH-001638	Lymphoma	CCLE	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.25
p.R202Q	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	KQVVFRD	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YI8	PHD finger protein 13	LIG_APCC_ABBAyCdc20_2	205:211	KQVVFRD	APC,CDC20,FZR1	0.9133	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons