DegronMD

Uniprot ID: Q10469

Source protein: Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Source gene: MGAT2

Class: LIG_APCC_ABBAyCdc20_2

Location: 403:409

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8796

ASA_SCORE: 79.9143

COIL: 0.5594

CONS_SCORE: 0.4161

DSS_SCORE: 0.3132

HELIX: 0.3744

FCONS_SCORE: 1.32

RIG_SCORE: 0.8134

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E396G	TCGA-19-5956	GBM	TCGA	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E396G	DO13863	GBM	ICGC	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.N402S	TCGA-19-5956	GBM	TCGA	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.N402S	DO13863	GBM	ICGC	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.F407L	TCGA-19-5956	GBM	TCGA	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.6981
p.F407L	DO13863	GBM	ICGC	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.6981
p.E409Q	TCGA-66-2758	LUSC	TCGA	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.6744
p.E409Q	DO26731	LUSC	ICGC	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.6744
p.I395S	DO233814	GACA	ICGC	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.I395V	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A393T	SIDM00293	Small Cell Lung Carcinoma	GDSC	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A393T	ACH-002052	Lung Cancer	CCLE	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A393T	LU-139	lung	COSMIC	KQYMFPE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q10469	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	LIG_APCC_ABBAyCdc20_2	403:409	KQYMFPE	APC,CDC20,FZR1	0.8796	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons