DegronMD

Uniprot ID: Q96G28

Source protein: Cilia- and flagella-associated protein 36

Source gene: CFAP36

Class: DEG_APCC_DBOX_1

Location: 279:287

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9751

ASA_SCORE: 106.8333

COIL: 0.1924

CONS_SCORE: 0.663

DSS_SCORE: 0.5986

HELIX: 0.8133

FCONS_SCORE: 1.2359

RIG_SCORE: 0.752

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V288A	SIDM00666	Glioma	GDSC	KRDKLMSMR	DEG_APCC_DBOX_1	0.3056
p.V288A	Hs683	central_nervous_system	COSMIC	KRDKLMSMR	DEG_APCC_DBOX_1	0.3056
p.I279T	SIDM01391	Neuroblastoma	GDSC	KRDKLMSMR	DEG_APCC_DBOX_1	0.7078
p.R297Q	NCI-H1417	lung	COSMIC	KRDKLMSMR	DEG_APCC_DBOX_1	0.0556
p.R272Q	NCI-H1417	lung	COSMIC	KRDKLMSMR	DEG_APCC_DBOX_1	0.1389
p.K288Q	NCI-N87	stomach	COSMIC	KRDKLMSMR	DEG_APCC_DBOX_1	0.3056
p.E273D	HT-115	large_intestine	COSMIC	KRDKLMSMR	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96G28	Cilia- and flagella-associated protein 36	DEG_APCC_DBOX_1	279:287	KRDKLMSMR	APC,CDC20,FZR1	0.9751	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons