DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KREELLSVP
Uniprot ID:
Q7Z2Y8
Source protein:
Interferon-induced very large GTPase 1
Source gene:
GVINP1
Class:
DEG_APCC_DBOX_1
Location:
202:210
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.889
ASA_SCORE:
64.6
COIL:
0.5659
CONS_SCORE:
0.3965
DSS_SCORE:
0.3901
HELIX:
0.2898
FCONS_SCORE:
1.3648
RIG_SCORE:
0.794
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GVINP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KREELLSVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z2Y8
Interferon-induced very large GTPase 1
DEG_APCC_DBOX_1
202:210
KREELLSVP
APC,CDC20,FZR1
0.889
More...