DegronMD

Uniprot ID: Q9Y3U8

Source protein: 60S ribosomal protein L36

Source gene: RPL36

Class: DEG_APCC_DBOX_1

Location: 86:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9031

ASA_SCORE: 80.8889

COIL: 0.0338

CONS_SCORE: 0.798

DSS_SCORE: 0.408

HELIX: 0.9647

FCONS_SCORE: 1.0053

RIG_SCORE: 0.7958

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I81M	TCGA-A8-A06Q	BRCA	TCGA	KREELSNVL	DEG_APCC_DBOX_1	0.1944
p.I81M	DO1263	BRCA	ICGC	KREELSNVL	DEG_APCC_DBOX_1	0.1944
p.A83T	TCGA-AA-A010	COAD	TCGA	KREELSNVL	DEG_APCC_DBOX_1	0.25
p.R84M	DO228976	LICA	ICGC	KREELSNVL	DEG_APCC_DBOX_1	0.2778
p.G86W	DO229038	LICA	ICGC	KREELSNVL	DEG_APCC_DBOX_1	0.7825
p.V87G	DO219881	SKCA	ICGC	KREELSNVL	DEG_APCC_DBOX_1	0.7532
p.T79A	DO229453	SKCA	ICGC	KREELSNVL	DEG_APCC_DBOX_1	0.5833
p.A95V	DO38404	STAD	ICGC	KREELSNVL	DEG_APCC_DBOX_1	0.3056
p.R85T	SIDM00578	Neuroblastoma	GDSC	KREELSNVL	DEG_APCC_DBOX_1	0.3056
p.R85T	ACH-000804	Neuroblastoma	CCLE	KREELSNVL	DEG_APCC_DBOX_1	0.3056
p.R98W	ACH-000937	Leukemia	CCLE	KREELSNVL	DEG_APCC_DBOX_1	0.2222
p.P83S	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	KREELSNVL	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3U8	60S ribosomal protein L36	DEG_APCC_DBOX_1	86:94	KREELSNVL	APC,CDC20,FZR1	0.9031	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons