DegronMD

Uniprot ID: Q6P3S1

Source protein: DENN domain-containing protein 1B

Source gene: DENND1B

Class: DEG_APCC_DBOX_1

Location: 703:711

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9954

ASA_SCORE: 97.9889

COIL: 0.8117

CONS_SCORE: 0

DSS_SCORE: 0.5665

HELIX: 0.1366

FCONS_SCORE: 0

RIG_SCORE: 0.7726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R721Q	SIDM00544	Neuroblastoma	GDSC	KRETLSQIS	DEG_APCC_DBOX_1	0.0556
p.R721Q	SIDM00287	B-Lymphoblastic Leukemia	GDSC	KRETLSQIS	DEG_APCC_DBOX_1	0.0556
p.R721Q	SIDM01460	Glioma	GDSC	KRETLSQIS	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P3S1	DENN domain-containing protein 1B	DEG_APCC_DBOX_1	703:711	KRETLSQIS	APC,CDC20,FZR1	0.9954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons