DegronMD

Uniprot ID: Q9NRF2

Source protein: SH2B adapter protein 1

Source gene: SH2B1

Class: DEG_APCC_DBOX_1

Location: 151:159

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9938

ASA_SCORE: 79.4444

COIL: 0.547

CONS_SCORE: 0.6532

DSS_SCORE: 0.4891

HELIX: 0.2837

FCONS_SCORE: 1.2495

RIG_SCORE: 0.7515

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T143A	TCGA-CM-4746	COAD	TCGA	KRFSLRSVG	DEG_APCC_DBOX_1	0.1111
p.T143A	DO7882	COAD	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.1111
p.R156H	TCGA-CM-6674	COAD	TCGA	KRFSLRSVG	DEG_APCC_DBOX_1	0.7133
p.R156H	TCGA-FP-A4BE	STAD	TCGA	KRFSLRSVG	DEG_APCC_DBOX_1	0.7133
p.R156H	DO10092	COAD	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.7133
p.R156H	DO50660	ORCA	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.7133
p.R156H	DO48016	STAD	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.7133
p.S165L	TCGA-DD-A3A2	LIHC	TCGA	KRFSLRSVG	DEG_APCC_DBOX_1	0.6111
p.S165L	DO44881	LIHC	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.6111
p.R152H	TCGA-EO-A22R	UCEC	TCGA	KRFSLRSVG	DEG_APCC_DBOX_1	0.8244
p.R152H	DO230320	COCA	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.8244
p.R152H	DO42713	UCEC	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.8244
p.R163Q	TCGA-LB-A7SX	PAAD	TCGA	KRFSLRSVG	DEG_APCC_DBOX_1	0.2222
p.R163Q	DO230347	COCA	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.2222
p.R163Q	DO49409	PAAD	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.2222
p.R156L	TCGA-MP-A4T4	LUAD	TCGA	KRFSLRSVG	DEG_APCC_DBOX_1	0.7316
p.R156L	DO45357	LUAD	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.7316
p.R167C	DO222817	BTCA	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.1111
p.T148A	DO230334	COCA	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.3611
p.T148A	DO228941	LICA	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.3611
p.T148A	DO229047	LICA	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.3611
p.G169W	DO22237	LGG	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.0556
p.G169W	DO41235	UCEC	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.0556
p.T168R	DO24409	LUAD	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.0833
p.P153S	DO220872	MELA	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.6752
p.L149I	DO50682	ORCA	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.2778
p.E165K	DO37418	SKCM	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.6111
p.P164L	DO229245	THCA	ICGC	KRFSLRSVG	DEG_APCC_DBOX_1	0.1944
p.P164L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	KRFSLRSVG	DEG_APCC_DBOX_1	0.1944
p.V162I	SIDM00660	Colorectal Carcinoma	GDSC	KRFSLRSVG	DEG_APCC_DBOX_1	0.25
p.V162I	ACH-000985	Colon/Colorectal Cancer	CCLE	KRFSLRSVG	DEG_APCC_DBOX_1	0.25
p.V162I	LS-411N	large_intestine	COSMIC	KRFSLRSVG	DEG_APCC_DBOX_1	0.25
p.A145T	ACH-000911	Gastric Cancer	CCLE	KRFSLRSVG	DEG_APCC_DBOX_1	0.1667
p.A145T	NUGC-3	stomach	COSMIC	KRFSLRSVG	DEG_APCC_DBOX_1	0.1667
p.R165C	ACH-002189	Kidney Cancer	CCLE	KRFSLRSVG	DEG_APCC_DBOX_1	0.6111
p.R165C	RCC-FG2	kidney	COSMIC	KRFSLRSVG	DEG_APCC_DBOX_1	0.6111
p.P160L	MCC13	skin	COSMIC	KRFSLRSVG	DEG_APCC_DBOX_1	0.3056
p.R165H	LS-1034	large_intestine	COSMIC	KRFSLRSVG	DEG_APCC_DBOX_1	0.6111
p.P160T	TC-71	bone	COSMIC	KRFSLRSVG	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRFSLRSVG

Degron related mutations and impact score

Drug responses associated with SH2B1 mutations

All proteins holding degron of KRFSLRSVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRF2	SH2B adapter protein 1	DEG_APCC_DBOX_1	151:159	KRFSLRSVG	APC,CDC20,FZR1	0.9938	More...