DegronMD

Uniprot ID: P53675

Source protein: Clathrin heavy chain 2

Source gene: CLTCL1

Class: DEG_APCC_DBOX_1

Location: 851:859

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5898

ASA_SCORE: 80.6889

COIL: 0.4077

CONS_SCORE: 0.7011

DSS_SCORE: 0.1076

HELIX: 0.5771

FCONS_SCORE: 1.2214

RIG_SCORE: 0.878

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V846L	TCGA-13-1411	OV	TCGA	KRNRLKLLL	DEG_APCC_DBOX_1	0.1944
p.V846L	DO32103	OV	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.1944
p.L845S	TCGA-A5-A0G2	UCEC	TCGA	KRNRLKLLL	DEG_APCC_DBOX_1	0.1667
p.L845S	DO41235	UCEC	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.1667
p.T842I	TCGA-BG-A0LX	UCEC	TCGA	KRNRLKLLL	DEG_APCC_DBOX_1	0.5278
p.T842I	DO41919	UCEC	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.5278
p.R852I	TCGA-BS-A0UV	UCEC	TCGA	KRNRLKLLL	DEG_APCC_DBOX_1	0.8102
p.R852I	DO222762	COCA	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.8102
p.R852I	DO42793	UCEC	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.8102
p.R852T	TCGA-CV-6936	HNSC	TCGA	KRNRLKLLL	DEG_APCC_DBOX_1	0.7876
p.R852T	DO14210	HNSC	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.7876
p.K851N	TCGA-EY-A1GI	UCEC	TCGA	KRNRLKLLL	DEG_APCC_DBOX_1	0.5806
p.K851N	DO222494	MELA	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.5806
p.K851N	DO41211	UCEC	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.5806
p.Q865H	TCGA-GN-A262	SKCM	TCGA	KRNRLKLLL	DEG_APCC_DBOX_1	0.1667
p.Q865H	DO37515	SKCM	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.1667
p.P860S	TCGA-Z2-A8RT	SKCM	TCGA	KRNRLKLLL	DEG_APCC_DBOX_1	0.3056
p.P860S	DO51301	SKCM	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.3056
p.R854G	DO233732	GACA	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.6457
p.P860T	DO46400	OV	ICGC	KRNRLKLLL	DEG_APCC_DBOX_1	0.3056
p.S864P	ACH-000966	Ovarian Cancer	CCLE	KRNRLKLLL	DEG_APCC_DBOX_1	0.1944
p.S864P	IGROV-1	ovary	COSMIC	KRNRLKLLL	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53675	Clathrin heavy chain 2	DEG_APCC_DBOX_1	851:859	KRNRLKLLL	APC,CDC20,FZR1	0.5898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons