DegronMD

Uniprot ID: P17861

Source protein: X-box-binding protein 1

Source gene: XBP1

Class: DEG_APCC_DBOX_1

Location: 60:68

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9995

ASA_SCORE: 106.9444

COIL: 0.7191

CONS_SCORE: 0.8544

DSS_SCORE: 0.6876

HELIX: 0.2697

FCONS_SCORE: 1.3247

RIG_SCORE: 0.6868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K72R	DO225012	BRCA	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.6667
p.E58V	DO234406	ESAD	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.2778
p.Q62L	DO228949	LICA	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.6654
p.H74N	DO229015	LICA	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.1667
p.P56S	DO27785	MALY	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.2222
p.R76K	DO52675	MALY	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.1111
p.R75M	DO52675	MALY	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.1389
p.D54H	DO52675	MALY	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.1667
p.S68R	DO228414	MALY	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.7427
p.K60E	DO228414	MALY	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.591
p.E71K	DO228418	MALY	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.25
p.L74P	DO228855	MALY	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.1667
p.R61Q	DO228858	MALY	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.7329
p.Q50R	DO51292	SKCM	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.0556
p.E71D	DO42793	UCEC	ICGC	KRQRLTHLS	DEG_APCC_DBOX_1	0.25
p.Q57H	SIDM00454	Rhabdomyosarcoma	GDSC	KRQRLTHLS	DEG_APCC_DBOX_1	0.25
p.R70Q	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	KRQRLTHLS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17861	X-box-binding protein 1	DEG_APCC_DBOX_1	60:68	KRQRLTHLS	APC,CDC20,FZR1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons