DegronMD

Uniprot ID: Q92665

Source protein: 28S ribosomal protein S31, mitochondrial

Source gene: MRPS31

Class: DEG_APCC_DBOX_1

Location: 122:130

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6873

ASA_SCORE: 116.5111

COIL: 0.6843

CONS_SCORE: 0.4402

DSS_SCORE: 0.6033

HELIX: 0.297

FCONS_SCORE: 0.9552

RIG_SCORE: 0.7416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T118A	TCGA-IB-7651	PAAD	TCGA	KRRPLKSLE	DEG_APCC_DBOX_1	0.2222
p.T118A	DO46657	PAAD	ICGC	KRRPLKSLE	DEG_APCC_DBOX_1	0.2222
p.T112K	DO228971	LICA	ICGC	KRRPLKSLE	DEG_APCC_DBOX_1	0.0556
p.T140A	SIDM00660	Colorectal Carcinoma	GDSC	KRRPLKSLE	DEG_APCC_DBOX_1	0.0556
p.T140A	LS-411N	large_intestine	COSMIC	KRRPLKSLE	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92665	28S ribosomal protein S31, mitochondrial	DEG_APCC_DBOX_1	122:130	KRRPLKSLE	APC,CDC20,FZR1	0.6873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons