DegronMD

Uniprot ID: P06213

Source protein: Insulin receptor

Source gene: INSR

Class: DEG_APCC_DBOX_1

Location: 760:768

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5654

ASA_SCORE: 82.8889

COIL: 0.6827

CONS_SCORE: 0.3127

DSS_SCORE: 0.6018

HELIX: 0.1078

FCONS_SCORE: 1.006

RIG_SCORE: 0.6687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T771A	TCGA-55-8506	LUAD	TCGA	KRRSLGDVG	DEG_APCC_DBOX_1	0.25
p.R761C	TCGA-AJ-A3BH	UCEC	TCGA	KRRSLGDVG	DEG_APCC_DBOX_1	0.8301
p.A778T	TCGA-AP-A0LE	UCEC	TCGA	KRRSLGDVG	DEG_APCC_DBOX_1	0.0556
p.D766N	TCGA-AP-A1DK	UCEC	TCGA	KRRSLGDVG	DEG_APCC_DBOX_1	0.5821
p.T771M	TCGA-AX-A1C5	UCEC	TCGA	KRRSLGDVG	DEG_APCC_DBOX_1	0.25
p.T776M	TCGA-BR-A4QL	STAD	TCGA	KRRSLGDVG	DEG_APCC_DBOX_1	0.1111
p.S775I	DO8224	COAD	ICGC	KRRSLGDVG	DEG_APCC_DBOX_1	0.1389
p.A766E	DO222777	ESCA	ICGC	KRRSLGDVG	DEG_APCC_DBOX_1	0.7701
p.T771N	DO229027	LICA	ICGC	KRRSLGDVG	DEG_APCC_DBOX_1	0.25
p.T759A	DO45390	LUAD	ICGC	KRRSLGDVG	DEG_APCC_DBOX_1	0.3056
p.P769L	DO37436	SKCM	ICGC	KRRSLGDVG	DEG_APCC_DBOX_1	0.3056
p.S773L	DO38123	SKCM	ICGC	KRRSLGDVG	DEG_APCC_DBOX_1	0.1944
p.T764M	DO38723	STAD	ICGC	KRRSLGDVG	DEG_APCC_DBOX_1	0.7423
p.A766T	DO43418	UCEC	ICGC	KRRSLGDVG	DEG_APCC_DBOX_1	0.7139
p.D754N	DO42033	UCEC	ICGC	KRRSLGDVG	DEG_APCC_DBOX_1	0.1667
p.T759M	DO41422	UCEC	ICGC	KRRSLGDVG	DEG_APCC_DBOX_1	0.3056
p.V774M	SIDM00782	Colorectal Carcinoma	GDSC	KRRSLGDVG	DEG_APCC_DBOX_1	0.1667
p.V774M	T84	large_intestine	COSMIC	KRRSLGDVG	DEG_APCC_DBOX_1	0.1667
p.P755S	SIDM00875	Breast Carcinoma	GDSC	KRRSLGDVG	DEG_APCC_DBOX_1	0.1944
p.P755S	SIDM00760	Small Cell Lung Carcinoma	GDSC	KRRSLGDVG	DEG_APCC_DBOX_1	0.1944
p.S773W	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	KRRSLGDVG	DEG_APCC_DBOX_1	0.1944
p.V762M	T84	large_intestine	COSMIC	KRRSLGDVG	DEG_APCC_DBOX_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06213	Insulin receptor	DEG_APCC_DBOX_1	760:768	KRRSLGDVG	APC,CDC20,FZR1	0.5654	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons