DegronMD

Uniprot ID: Q13501

Source protein: Sequestosome-1

Source gene: SQSTM1

Class: DEG_APCC_DBOX_1

Location: 264:272

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.856

ASA_SCORE: 103.1222

COIL: 0.8322

CONS_SCORE: 0.4752

DSS_SCORE: 0.6471

HELIX: 0.0212

FCONS_SCORE: 0.9405

RIG_SCORE: 0.6374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S266R	TCGA-A5-A1OF	UCEC	TCGA	KRSRLTPVS	DEG_APCC_DBOX_1	0.7427
p.S266R	DO42568	UCEC	ICGC	KRSRLTPVS	DEG_APCC_DBOX_1	0.7427
p.V255I	TCGA-CD-A4MG	STAD	TCGA	KRSRLTPVS	DEG_APCC_DBOX_1	0.0833
p.V255I	DO48009	STAD	ICGC	KRSRLTPVS	DEG_APCC_DBOX_1	0.0833
p.P264L	DO1658	BRCA	ICGC	KRSRLTPVS	DEG_APCC_DBOX_1	0.7582
p.P264L	DO42280	UCEC	ICGC	KRSRLTPVS	DEG_APCC_DBOX_1	0.7582
p.T266I	DO233764	GACA	ICGC	KRSRLTPVS	DEG_APCC_DBOX_1	0.7078
p.E261K	DO47278	SKCM	ICGC	KRSRLTPVS	DEG_APCC_DBOX_1	0.25
p.H256N	DO37707	SKCM	ICGC	KRSRLTPVS	DEG_APCC_DBOX_1	0.1111
p.V255L	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	KRSRLTPVS	DEG_APCC_DBOX_1	0.0833
p.V255L	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	KRSRLTPVS	DEG_APCC_DBOX_1	0.0833
p.T269A	ACH-000940	Endometrial/Uterine Cancer	CCLE	KRSRLTPVS	DEG_APCC_DBOX_1	0.7139
p.T269A	AN3-CA	endometrium	COSMIC	KRSRLTPVS	DEG_APCC_DBOX_1	0.7139
p.K281R	ACH-002027	Endometrial/Uterine Cancer	CCLE	KRSRLTPVS	DEG_APCC_DBOX_1	0.5278
p.L272P	MFE-319	endometrium	COSMIC	KRSRLTPVS	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13501	Sequestosome-1	DEG_APCC_DBOX_1	264:272	KRSRLTPVS	APC,CDC20,FZR1	0.856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons