DegronMD

Uniprot ID: Q9BWV3

Source protein: Cytidine and dCMP deaminase domain-containing protein 1

Source gene: CDADC1

Class: DEG_APCC_DBOX_1

Location: 86:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5632

ASA_SCORE: 36.6111

COIL: 0.2606

CONS_SCORE: 0.5279

DSS_SCORE: 0.306

HELIX: 0.0081

FCONS_SCORE: 1.3278

RIG_SCORE: 0.8536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R87I	TCGA-A5-A2K5	UCEC	TCGA	KRTGLVVVK	DEG_APCC_DBOX_1	0.8102
p.R87I	DO41379	UCEC	ICGC	KRTGLVVVK	DEG_APCC_DBOX_1	0.8102
p.I98S	TCGA-AZ-4315	COAD	TCGA	KRTGLVVVK	DEG_APCC_DBOX_1	0.2222
p.I98S	DO8842	COAD	ICGC	KRTGLVVVK	DEG_APCC_DBOX_1	0.2222
p.V92A	TCGA-BG-A222	UCEC	TCGA	KRTGLVVVK	DEG_APCC_DBOX_1	0.5825
p.V92A	DO42977	UCEC	ICGC	KRTGLVVVK	DEG_APCC_DBOX_1	0.5825
p.R83K	DO222649	ESCA	ICGC	KRTGLVVVK	DEG_APCC_DBOX_1	0.25
p.V92L	DO229026	LICA	ICGC	KRTGLVVVK	DEG_APCC_DBOX_1	0.5654
p.H102R	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRTGLVVVK	DEG_APCC_DBOX_1	0.1111
p.H102R	ACH-000158	Lymphoma	CCLE	KRTGLVVVK	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWV3	Cytidine and dCMP deaminase domain-containing protein 1	DEG_APCC_DBOX_1	86:94	KRTGLVVVK	APC,CDC20,FZR1	0.5632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons