DegronMD

Uniprot ID: O14672

Source protein: Disintegrin and metalloproteinase domain-containing protein 10

Source gene: ADAM10

Class: LIG_APCC_ABBAyCdc20_2

Location: 346:352

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8982

ASA_SCORE: 77.3429

COIL: 0.447

CONS_SCORE: 0.4491

DSS_SCORE: 0.3677

HELIX: 0.0253

FCONS_SCORE: 0.7629

RIG_SCORE: 0.7849

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S337L	TCGA-CF-A27C	BLCA	TCGA	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S337L	DO828	BLCA	ICGC	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.G342E	TCGA-DU-6393	LGG	TCGA	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G342E	DO22149	LGG	ICGC	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T360I	TCGA-ER-A19S	SKCM	TCGA	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T360I	DO47380	SKCM	ICGC	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.L349F	TCGA-J9-A8CK	PRAD	TCGA	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.6981
p.L349F	DO223660	PRAD	ICGC	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.6981
p.R355M	DO24596	LUAD	ICGC	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.3611
p.R343Q	DO26596	LUSC	ICGC	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.25
p.L358V	SIDM01588	Endometrial Carcinoma	GDSC	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.L358V	ACH-000993	Endometrial/Uterine Cancer	CCLE	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S347I	ACH-002027	Endometrial/Uterine Cancer	CCLE	KSKLYSD	LIG_APCC_ABBAyCdc20_2	0.623

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14672	Disintegrin and metalloproteinase domain-containing protein 10	LIG_APCC_ABBAyCdc20_2	346:352	KSKLYSD	APC,CDC20,FZR1	0.8982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons