DegronMD

Uniprot ID: P19474

Source protein: E3 ubiquitin-protein ligase TRIM21

Source gene: TRIM21

Class: LIG_APCC_ABBAyCdc20_2

Location: 175:181

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7841

ASA_SCORE: 76.8

COIL: 0.0101

CONS_SCORE: 0.5468

DSS_SCORE: 0.2999

HELIX: 0.9899

FCONS_SCORE: 1.1843

RIG_SCORE: 0.7839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A165S	TCGA-76-6656	GBM	TCGA	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A165S	DO13671	GBM	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A165S	DO35192	PACA	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A180T	TCGA-AX-A2H7	UCEC	TCGA	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.6028
p.A180T	DO41044	UCEC	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.6028
p.N187S	TCGA-BR-6452	STAD	TCGA	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N187S	DO38404	STAD	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.T170A	TCGA-D1-A103	UCEC	TCGA	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.1944
p.T170A	DO42312	UCEC	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.1944
p.F188Y	TCGA-DI-A1BU	UCEC	TCGA	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.F188Y	DO42023	UCEC	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V190I	TCGA-HU-A4GU	STAD	TCGA	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V190I	DO47849	STAD	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S176F	TCGA-RP-A693	SKCM	TCGA	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.6871
p.S176F	DO51268	SKCM	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.6871
p.K175N	DO222884	COCA	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.6918
p.A165E	DO234256	ESAD	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.T173K	DO229032	LICA	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.H179N	DO229031	LICA	ICGC	KSRIHAE	LIG_APCC_ABBAyCdc20_2	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19474	E3 ubiquitin-protein ligase TRIM21	LIG_APCC_ABBAyCdc20_2	175:181	KSRIHAE	APC,CDC20,FZR1	0.7841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons